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Bradykinin-induced angioedema and its differential diagnosis


Authors: P. Králíčková 1;  E. Malá 1;  P. Rozsíval 2;  Jana Krtičková 3;  I. Krčmová 1
Authors‘ workplace: Univerzita Karlova v Praze, Lékařská fakulta a Fakultní nemocnice Hradec Králové ;  Ústav klinické imunologie a alergologie, Přednosta: prof. RNDr. Jan Krejsek, CSc. 1;  Dětská klinika, Přednosta: prof. MUDr. Milan Bayer, CSc. 2;  Klinika otorinolaryngologie a chirurgie hlavy a krku, Přednosta: prof. MUDr. Viktor Chrobok, Ph. D. 3
Published in: Prakt. Lék. 2012; 92(7): 378-382
Category: Reviews

Overview

A significant proportion of population has experience with angioedema. According to the pathophysiology it is possible to subdivide angioedema into histamine- or bradykinin induced. They fundamentally differ from each other in aetiology, clinical picture and management. This article is focused on bradykinin-induced angioedema, comprising: hereditary angioedema, ACE-inhibitors induced-angioedema and acquired angioedema. These diagnoses are often neglected. Inadequate treatment could lead to a patient’s death. C1 inhibitor substitution and bradykinin-receptor blocker play key roles in the management of the condition. Corticosteroids, antihistamines or adrenalin are ineffective in such cases.

Key words:
angioedema, bradykinin, hereditary, C1 inhibitor, icatibant


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