Topical treatment of rheumatic diseases by non steroidal anti-inflammatory drugs

Czech version

Authors: K. Trnavský
Authors‘ workplace: Ředitel: MUDr. Zdeněk Hadra ; Vedoucí lékař: prof. MUDr. K. Trnavský, DrSc. ; Institut postgraduálního vzdělávání ve zdravotnictví, Praha ; Arthrocentrum Praha
Published in: Prakt. Lék. 2008; 88(4): 195-196
Category: Reviews

Overview

This review discusses the benefits of topical treatment of rheumatic diseases by non steroidal anti-inflammatory drugs. This treatment is widely used and there are an increasing number of clinical trials confirming its efficiency. Topical NSAID treatment is well tolerated and has fewer adverse effects than oral application. Although topical forms of NSAID are more expensive than oral ones, local treatment may be eventually cheaper from a long-term perspective.

Key words:
rheumatic diseases, non steroidal anti-inflammatory drugs, topical treatment.

Sources

1. Heyneman, C.A., Liday-Lawless, C., Wall, G.C. Oral versus topical NSAIDs in rheumatic diseases. Drugs 2000, 60, p. 555-574.

2. Lin, J., Zhang, W., Jones, A., Doherty, M. Efficacy of topícal non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials. BMJ 2004, 329, p. 324-329.

3. Moore, R.A., Tramer, M.R., Caroll, D. et al. Quantitative systemic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998, 316, p. 333-338.

4. Morris, V.H., Cruwys, S.C., Kidd, B.L. Characterisation of capsaicin-induced mechanical hyperalgesia as marker for altered nociceptive processing in patiens with rheumatoid arthritis. Pain 1997, 71, p. 179-186.

5. Olejárová M. Nimesulid ve formě gelu v léčbě muskuloskeletálních onemocnění. Farmakoterapie 2006, 2, s. 361-363.

6. Pavelka, K. Lokální nesteroidní antirevmatika. V: Farmakoterapie revmatických onemocnění. Praha: Grada 2005, s. 59-62.

7. Sengupta, S., Velpandian, T., Kabir, S.R., Gupta, S.K. Analgesic efficacy and pharmacokinetics of topical nimesulide gel in healthy human volunteers: double blind comparison with piroxicam, diclofenac and placebo. Eur. J. Clin. Pharmacol. 1998, 54, p. 541-547.

8. Trnavský, K., Fischer, M., Vogtle-Junkert, U., Schreyger, F. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. J. Rheumatol. 2004, 31, p. 565-572.

9. Vaile, J.H., Davis, P. Topical NSAIDs for the musculoskeletal conditions. Drugs 1998, 56, p. 783-799.