Possible Immunological Diagnosis of Psoriasis Vulgaris

Overview

The authors divided 43 patients with psoriasis into two groups. Group 1 comprised 21 patients with the dermal form of psoriasis only, incl. 9, with the acute and 12 with the chronic form. The second group comprised 22 patients with affections of the joints, inc. 9 who suffered from the articular form only and 13 also from the chronic dermal form.The authors examined in all patients the immunological profile and made immunohistological examinations of the psoriatic skin. Examination of the immunological profile revealed significantly raised IgM in the acute form of psoriasis, significantly raised IgG in the chronic form where they found also significantly reduced active and total E rosettes. Immunohistological examination revealed immunocomplexes with IgG, IgA, IgM, C3 and fibrin in the stratum corneum more frequently in acute forms of psoriasis with affection of the skin. In patients with the articular form of psoriasis they detected immunocomplexes with IgG, IgM and fibrin in the vascular walls of the corium.In the conclusion the authors state that impaired immunity in the peripheral blood stream and the finding of immunocomplexes in the stratum corneum and the corial vessels confirm that psoriasis in an autoimmune disease.

Key words:
psoriasis - immunological profile - immunohistological examination of psoriatic morpheae.