Authors: R. Kotas Authors‘ workplace: Neurologická klinika FN a LF UK, Plzeň, přednosta prof. MUDr. Z. Ambler, DrSc. Published in: Prakt. Lék. 1999; (9): 498-500 Category:
This review describes the etiopathogenesis of migraine. The basis for the development ofa migrainous attack is a primary neuronal dysfunction similar to experimental Leao’s sprea-ding depression. Neuronal depolarization followed by suppression of neuronal activity spreadsin a wave across the surface of the brain, accompanied by cerebral blood flow changes. Theseare detectable in migraine with aura by SPECT (single photon emission computed tomography)or in migraine without aura by PET (positron emission tomography). Consequently activationof the trigeminovascular system occurs and the neurogenic sterile inflammation in the vesselwall of intracranial arteries develops which is responsible for the painful phase.
Key words: Leao’s spreading depression - trigeminovascular system - sterile perivascularinflammation.
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