Linear Regression Analysis of Values of theCalciuria Index, N-telopetide and Bone Mineral Density in Patients with Osteoporosis

Czech version

Authors: V. Chvála
Authors‘ workplace: Osteologická ambulancia, Fakultná NsP akademika L. Dérera, Bratislava, riaditeľ MUDr. V. Hladík 2 Ústav klinickej a preventívnej medicíny, Bratislava, riaditeľ prof. MUDr. T. Trnovec, DrSc. 3 Oddelenie klinickej biochémie, Onkologický ústav sv. Alžbety, B
Published in: Prakt. Lék. 1999; (5): 159-162
Category:

Overview

The authors examined 49 patients (n=49) with primary and secndary osteoporosis incl. 37 womenaged 41-58 years and 12 men aged 38-56 years. In all they assessed the 24-hour calciuria index(Ca/creatinine), the aminoterminal N-telopetide of collagen I of the organic matrix (NTx24) andthe bone mineral density (BMD) in the first three lumbar vertebrae using quantitative computedtomography (QC).Objective: To find an answer to the questions:1. Is the calciuria index in the24-hour diuresis a parameter which provides information on osteresorption? 2. Is there a signifi-cant negative correlation between values NTx24 and BMD? 3. Is NTx a sensitive parameter ofosteoresorption in men and women with primary or secondary osteoporosis? Statistical analysis:Linear regression analysis. Results: Correlation coefficients for the correlated groups NTx24 -Ca/creatinine (r= 0.023, p>0.05) and NTx24 - BMD (r= - 0.238, p>0.05) were not statistically signifi-cant. Statistical significance was recorded in the correlation coefficient for pathologically eleva-ted values of NTx24(zNTx24), correlated with BMD (r = -0.3115, p

Key words:
N-telopetide - Calciuria - Bone mineral density - Bone metabolism - Osteoporosis.

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