Current options for drug therapy in perianal Crohn’s disease

Czech version

Authors: M. Lukáš
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty, Klinické centrum ISCARE a. s. a 1. LF UK v Praze
Published in: Gastroent Hepatol 2026; 80(3): 250-254
Category: IBD: Review Article
doi: https://doi.org/10.48095/ccgh2026250

Overview

Perianal lesions in Crohn’s disease occur in 20–30% of patients, which are divided into perforating and non-perforating phenotypes, where recurrent perianal abscesses and fistulas appear more frequently. Diagnosis and therapy of perianal Crohn’s disease has changed dramatically in the last couple of years. Close cooperation of gastroenterologists with experienced colorectal surgeons using the “conservative” surgical approach is critical. In medicamentous therapy, infliximab and antibiotics have been used for many years, but recently new drugs were introduced such as upadacitinib. This year, the results of a FUZION study have been published showing that guselkumab is effective in those patients. This overview summarised the current role of medicamentous therapy in patients with perianal Crohn’s disease.

Keywords:

perianal Crohn’s disease – infliximab – upadacitinib – guselkumab

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