A neuroendocrine tumor of the stomach in a patient with Jervell-Lange-Nielsen syndrome –⁠ a case report

Czech version

Authors: O. Částka ¹; Z. Papík ¹; Š. Málková ¹; R. Kolářová ¹; V. Kozová ¹; B. Navrátilová ²
Authors‘ workplace: Gastroenterologická a hepatologická poradna, Oblastní nemocnice Náchod a. s. ¹; Oddělení patologické anatomie a cytologie, Oblastní nemocnice Náchod a. s. ²
Published in: Gastroent Hepatol 2026; 80(3): 234-238
Category: Gastrointestinal Oncology: Original Article
doi: https://doi.org/10.48095/ccgh2026234

Overview

We present a rare case of a gastric neuroendocrine tumor in a young man with Jervell-Lange-Nielsen syndrome. The disease manifested clinically with nonspecific dyspeptic symptoms and was associated with achlorhydria in the absence of atrophic gastritis. The tumor infiltrating the gastric mucosa and submucosa was diagnosed based on histological and immunohistochemical examination of a biopsy specimen, which was confirmed positive for synaptophysin. No lymph node involvement or evidence of disease dissemination was found.

Keywords:

gastric neuroendocrine tumor – Jervell-Lange-Nielsen syndrome – achlorhydria

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