Appropriate timing of bowel cleansing using low-volume preparations

Authors: Kojecký V. 1;  Matouš J. 2;  Kianička B. 3;  Zádorová Z. 2;  Varga M. 1
Authors‘ workplace: Interní oddělení, Krajská nemocnice T. Bati, Zlín 1;  II. interní klinika FN Královské Vinohrady a III. LF UK, Praha 2;  II. interní klinika FN u sv. Anny v Brně 3
Published in: Gastroent Hepatol 2019; 73(3): 228-232
Category: Digestive Endoscopy: Original Article
doi: 10.14735/amgh2019228


Introduction: The outcome of bowel preparation depends on several factors. One such factor is proper timing, especially the duration from completion of the preparation to colonoscopy. This interval should not exceed 4 hours when using polyethylene glycol (PEG). It is unknown whether this recommendation is also valid for low-volume formulas. This study aimed to determine the appropriate timing of bowel cleansing using such formulas.

Methods: Subjects referred for a colonoscopy were prepared using PEG/ascorbic acid (MOV), picosulphate/magnesium citrate (PICO), or sulphate solution (EZI). The quality, tolerability, length of the preparation (T-pripr), and interval from completion of the preparation to colonoscopy (T-vys) were assessed.

Results: Preparation quality depended on both T-pripr and T-vys (p ≤ 0.006). The predicted T-pripr in the two best preparations was longer for PICO than for EZI and MOV (> 9.0 vs. > 7.0 and > 6.5 hours, p = 0.01). T-vys was also longest for PICO (≤ 13.0 hours, p = 0.001). There was no difference between MOV and EZI (≤ 10 and ≤ 11 hours). Time factors did not affect preparation tolerability.

Conclusion: The quality of bowel cleansing depends not only on the interval to colonoscopy but also on the length of the preparation. Optimal time points are comparable for osmotically acting low-volume laxatives, but longer for PICO. Time factors do not affect preparation tolerability.


colonoscopy – time factors – bowel preparation


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Paediatric gastroenterology Gastroenterology and hepatology Surgery
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