Efficacy of ustekinumab in a patient refractory to other biological treatment

Czech version

Authors: M. Bortlík ^1–3; N. Machková ¹; V. Hrubá ¹; M. Lukáš Jr. ¹; D. Ďuricová ¹; K. Malíčková ^1,4; Z. Šerclová ⁵; M. Lukáš ^1,4
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty ISCARE I. V. F. a. s., Praha a 1. LF UK v Praze ¹; Interní klinika 1. LF UK a ÚVN – VFN Praha ²; Farmakologický ústav, 1. LF UK a VFN v Praze ³; Ústav lékařské biochemie a laboratorní diagnostiky, 1. LF UK a VFN v Praze ⁴; Chirurgické oddělení, NH Hospital, a. s., Nemocnice Hořovice ⁵
Published in: Gastroent Hepatol 2018; 72(1): 47-49
Category: IBD: Case Report
doi: https://doi.org/10.14735/amgh201847

Overview

This case report describes a female patient who was diagnosed at the age of 11 with Crohn’s disease with ileocecal and perianal localization. The disease course was progressive, and conventional therapy was ineffective. The patient did not tolerate long-term treatment with anti-TNF antibodies. Next, therapy with an anti-integrin antibody was given, which had some efficacy for the luminal disease, but none for the perianal disease. Therefore, in June, 2017, we initiated therapy with ustekinumab. The patient responded within 6 weeks, with clear improvement of bowel symptoms as well as perianal disease. We have not observed any adverse effects of ustekinumab in this patient.

Key words:
Crohn‘s disease – biological treatment – ustekinumab

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
29. 1. 2018

Accepted:
1. 2. 2018

Sources

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