Diabetes mellitus and skin disorders

Authors: Klaudia Péčová Jr;  Juraj Péč;  Roman Šutka
Authors‘ workplace: Dermatovenerologická klinika Jesseniovej LF UK a UNM, Martin
Published in: Forum Diab 2017; 6(1): 31-36


The authors analyze the problems of incidence of skin disorders associated with diabetes mellitus, most frequently with its second type. They present a brief overview of a possible impact of glucose and insulin on individual structures of dermis. They divide diseases associated with diabetes mellitus, based on literary data, into 5 groups: diabetic angiopathy and neuropathy (diabetic foot, legs ulceration, diabetic bulla, erysipeloid erythema, diabetic rubeosis), skin and mucous tissue infections (bacterial, mycotic, viral and Kaposi sarcoma), immune-mediated dermatoses (necrobiosis lipoidica diabeticorum, granuloma anulare disseminatum, scleredema diabeticorum, pemphigoid, vitiligo, psoriasis, lichen ruber planus, reactive perforating collagenosis), metabolism-related dermatoses (yellow nail syndrome and wax-like skin, diabetic stiffening of joints, eruptive skin xanthomas, carotenoderma, hemochromatosis, porphyria cutanea tarda) and insulin-related dermatoses (acanthosis nigricans, multiple fibroma molle related to obesity, pruritus, lipodystrophy – local skin reactions to insulin and systemic allergic erythema, lipoatrophy, lipohyperthrophy). The authors point to the refractory character of treatment of some of the above mentioned diseases, as not every modification of glycaemia can bring a benefit in their treatment.

Key words:
diabetes mellitus, diabetic angiopathy and neuropathy, skin and mucous tissue infections, immune-mediated dermatoses, metabolism-related dermatoses, insulin-related dermatoses

10. 2. 2017

1. 3. 2017


1. Romano G, Moretti G, Di Benedetto A. Skin lesions in diabetes mellitus: Prevalence and clinical correlation. Diabetes Res Clinic Pract 1998; 39(2): 101–106.

2. Vohradníková O, Perušicová J. Kožní projevy pri diabetes mellitus. Maxdorf Jessenius: Praha 1996. ISBN 80–85800–38–1.

3. Mahajan S, Korrane RV, Sharma SK. Cutaneous manifestation of diabetes mellitus. Indian J Dermatol Venerol Leprosy 2003; 69(2): 105–108.

4. Frykberg RG, Zgonis T, Armstrong D et al. Diabetic foot disorders: a clinical practice guidelines. J Foot Ankle Surg 2006; 39(5): 1–60.

5. Palencarova E, Plank L, Straka S et al. Phaeohyphomycosis due to Alternaria spp. and Phaeosclera dematioides: a histopathological study. Mycoses 1995; 39(2): 207–221.

6. Pec J, Minarikova E, Zaborska D et al. Treatment of dermal and subcutaneous pheaohyphomycosis of 55 years´s duration. Int J Dermatol 2008; 47(5): 526–529. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365–4632.2008.03415.x>.

7. Babal P, Pec J. Kaposi´s sarcoma-still an enigma. J Eur Acad Dermatol Venereol (JEADV) 2003; 17(4): 377–380.

8. Krause WK. Diabetes mellitus and glucagonoma 121–137. In Krause WK, Jabbour S. Cutaneous manifestations of endocrine disease. Springer: Berlin Heidelberg 2009. ISBN 978–3642100024.

9. Pec J, Martinka E, Mokan M et al. Scleroderma diabeticorum in a patient with latent autoimmune diabetes in adults (LADA). Eur J Dermatol 1997; 7: 596–598.

10. Filo V, Buchvald J, Rasochova E et al. Perforating lipoidic necrosis: successful treatment with cyclosporin. Am J Dermatol Treatment 1998; 9: 41–43.

11. Filo V, Pec J. Lipomatosis benigna symmetrica – Launois-Bensaud syndrome. Diagnosis: Launois-Bensaud syndrome (1898). Eur J Dermatol 1996; 6: 533- 534.

12. Informace dostupné z WWW: <http://betablog.org/wp-content/uploads/2015/08/Kaposis-sarcoma-photo-credit-National-Cancer-Institute.jpg>.

Diabetology Endocrinology Internal medicine
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