Vitamin D and the Metabolic Syndrome among Women with the Polycystic Ovarian Syndrome


Authors: Jana Figurová 1;  Ingrid Dravecká 1;  Jana Petríková 1;  Martin Javorský 2;  Darina Petrášová 3;  Ivica Lazúrová 1
Authors‘ workplace: I. interná klinika LF UPJŠ a UN L. Pasteura, Košice, primár MUDr. Mikuláš Szakács 1;  IV. interná klinika LF UPJŠ a UN L. Pasteura, Košice, prednosta prof. MUDr. Ivan Tkáč, PhD. 2;  Laboratórium výskumných biomodelov LF UPJŠ, Košice, vedúci pracoviska RNDr. Darina Petrášová, PhD. 3
Published in: Forum Diab 2014; 3(3): 143-148
Category: Topic

Overview

Introduction:
The polycystic ovarian syndrome (PCOS) is one of the most frequently occurring endocrinopathies among women of childbearing potential with a 4-18% prevalence. Besides the menstrual cycle disorder with subsequent fertility problems, hyperandrogenaemia and its skin manifestations, we also find multiple metabolic abnormalities among these women, namely a high occurrence of individual manifestations of the metabolic syndrome (MetS) and cardiovascular risk factors. The occurrence of hypovitaminosis D among a population of patients with MetS symptoms, as well as among a group of women with PCOS extends the research on a possible effect of vitamin D on the phenotypic manifestation of PCOS.

Target of the study:
Establish the organism saturation with vitamin D among women with PCOS and in the control cohort (CC), evaluate the relation of hypovitaminosis D to individual symptoms of MetS in PCOS.

Methods:
25(OH)D, basic anthropometric and metabolic parameters, the overall amount of fat tissue and its distribution across the android and gynoid regions were established for a cohort of 99 women diagnosed with PCOS according to the Rotterdam criteria and for 66 women in the control cohort.

Results:
We have not confirmed a significant difference in the average serum levels of 25(OH)D between PCOS and CC (24.79 ± 10.77 vs 25.07 ± 10.14 ng/ml, p = 0.868). The patients with PCOS meeting the MetS criteria had significantly lower values of 25(OH)D as compared with PCOS without MetS (20.6 ± 8.3 vs 25.9 ± 11.3 ng/ml, p = 0.049). PCOS patients with hypovitaminosis had higher levels of triglycerides of limit significance (1.44 ± 0.93 vs 1.03 ± 0.46, p = 0.051) and a trend toward a higher HOMA-index (median [percentile]: 2.24 [1.38; 3.51] vs 1.85 [1.04; 3.68], p = 0.467) as compared with the women manifesting PCOS with normal vitamin D saturation. 25(OH)D correlated positively with HDL-cholesterol (r = 0.159, p = 0.043) among all individuals.

Conclusion:
Low levels of 25(OH)D are associated with individual elements of the MetS in the PCOS, though not with the PCOS itself.

Key words:
insulin resistance – metabolic syndrome – polycystic ovarian syndrome – vitamin D


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Labels
Diabetology Endocrinology Internal medicine
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