Empagliflozin in patients with chronic kidney disease: results of the EMPA-KIDNEY trial and implications for clinical practice

Czech version

Authors: Peter Novodvorský ^1,2,3
Authors‘ workplace: metabolické centrum s. r. o., Trenčín ¹; Centrum diabetologie IKEM, Praha ²; Department of Oncology and Metabolism, Medical School, University of Sheffield, United Kingdom ³
Published in: Diab Obez 2023; 23(45): 49-53
Category:

Overview

Chronic kidney disease (CKD) is defined by the decrease of estimated glomerular filtration rate (eGFR) or the presence of albuminuria, or both and globally affects > 850 million people. Diabetes is one of the leading causes of CKD, but, on the other hand, the majority of people with CKD do not have diabetes. Empagliflozin is a sodium- glucose co-transporter 2 inhibitor (SGLT2i) with cardiovascular benefits proven by several large clinical trials. EMPA-KIDNEY trial examined the effect of empagliflozin (10 mg/day) vs placebo on the primary composite outcome of CKD progression (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml/ min/1.73 m², a sustained decrease in eGFR of ≥ 40 % from baseline or death from renal causes) or death from cardiovascular causes. In this article, I discuss the major aspects and outcomes of the EMPA-KIDNEY trial and its implications for clinical practice.

Keywords:

empagliflozin – type 2 diabetes – chronic kidney disease (CKD) – sodium-glucose co-transporter 2 inhibitors (SGLT2i)

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