The value of immunohistochemical methods in diagnosing endometrial carcinoma

Czech version

Authors: Pavel Dundr ¹; Kristýna Němejcová ¹; Michaela Bártů ¹; Rosalie Jana Bennett ¹; Helena Skálová ¹; Pavol Janega ^2,3; Ivana Stružinská ¹
Authors‘ workplace: Ústav patologie 1. LF UK a VFN v Praze ¹; Ústav patologickej anatómie, Lekárska fakulta, Univerzita Komenského v Bratislave ²; Medirex Group Academy, Trnava, n. o. ³
Published in: Čes.-slov. Patol., 57, 2021, No. 2, p. 73-85
Category: Reviews Article

Overview

The goal of this manuscript is to provide an overview of the significance of immunohistochemical methods in diagnosing endometrial carcinoma. The main points discussed include: the use of immunohistochemistry in the differential diagnosis of the main histological types of endometrial carcinoma, the difference between primary serous endometrial carcinoma and the involvement with high grade serous carcinoma of another primary source, the diagnosis of undifferentiated/dedifferentiated endometrial carcinoma, and diagnosing tumours with neuroendocrine differentiation. The role of p53 expression evaluation is also emphasized as a special area of interest, not only in the context of differential diagnosis, but also from the point of view of the prognosis and prediction of endometrial carcinoma as an ancillary marker for subtypization of these tumours.

Keywords:

Endometrial carcinoma – endometrioid carcinoma – serous carcinoma – clear cell carcinoma – undifferentiated / dedifferentiated carcinoma – immunohistochemistry

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