Frozen section of lung, pleura and mediastinum specimen: Retrospective analysis of 5-years practical experiences and review of the literature
Authors:
Zuzana Mouchová 1,2,3; Blanka Rosová 1,2; Radoslav Matěj 1,2,3
Authors‘ workplace:
Oddělení patologie a molekulární medicíny, Thomayerova nemocnice, Praha
1; Ústav patologie, 3. lékařská fakulta Univerzity Karlovy a FNKV, Praha
2; Ústav patologie, 1. lékařská fakulta Univerzity Karlovy a VFN, Praha
3
Published in:
Čes.-slov. Patol., 54, 2018, No. 3, p. 127-131
Category:
Reviews Article
Overview
Thoracic frozen section biopsies including lungs, pleura and mediastinum have crucial role in differential diagnosis of solitary lesions of the lungs and mediastinum. There is a significant difference in patient´s therapeutical management, if the patients suffer from lung primary malignant tumour, metastasis or non-malignant lesion. In this review, we summarize the usefulness of frozen section biopsies in thoracic surgery and provide 5-years of experiences with thoracic frozen section biopsies performed at the Department of Pathology and Molecular Medicine of Thomayer Hospital in Prague.
Keywords:
frozen section – lung – mediastinum
Sources
1. Sienko A, Allen TC, Zander DS, Cagle PT. Frozen section of lung specimens. Arch Pathol Lab Med 2005; 129(12): 1602-1609.
2. Van Schil PE, Balduyck B, De Waele M, Hendriks JM, Hertoghs M, Lauwers P. Surgical treatment of early-stage non-small-cell lung cancer. EJC Suppl 2013; 11(2): 110-122.
3. Sugarbaker DJ. Lung cancer. 6: The case for limited surgical resection in non-small cell lung cancer. Thorax 2003; 58(7): 639-641.
4. Marchevsky AM, Changsri C, Gupta I, Fuller C, Houck W, McKenna RJ, Jr. Frozen section diagnoses of small pulmonary nodules: accuracy and clinical implications. Ann Thorac Surg 2004; 78(5): 1755-1759.
5. Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG, eds. WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. IARC Lyon 2015; 4th ed.
6. Matěj R, Vedralová J, Koukolík F. Imunohistochemický průkaz TTF-1 v peroperačních bioptických vzorcích plicních adenokarcinomů: roční zkušenosti. Cesk Patol 2008; 44(2): 41-44.
7. Ikeda K, Clark JC, Shaw-White JR, Stahlman MT, Boutell CJ, Whitsett JA. Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem 1995; 270(14): 8108-8114.
8. Lazzaro D, Price M, de Felice M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 1991; 113(4): 1093-1104.
9. Moldvay J, Jackel M, Bogos K, et al. The role of TTF-1 in differentiating primary and metastatic lung adenocarcinomas. Pathol Oncol Res 2004; 10(2): 85-88.
10. Zámečník J, Kodet R. Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch 2002; 440(4): 353-361.
11. Owen RM, Force SD, Gal AA, et al. Routine intraoperative frozen section analysis of bronchial margins is of limited utility in lung cancer resection. Ann Thorac Surg 2013; 95(6): 1859-1865; discussion 1865-1856.
12. Trousse D, Avaro JP. Mediastinal tumors: introduction. Rev Pneumol Clin 2010; 66(1): 3-16.
13. Lardinois D. Pre- and intra-operative mediastinal staging in non-small-cell lung cancer. Swiss Med Wkly 2011; 141w13168.
14. Attaran S, Jakaj G, Acharya M, Anderson JR. Are frozen sections of mediastinoscopy samples as effective as formal paraffin assessment of mediastinoscopy samples for a decision on a combined mediastinoscopy plus lobectomy? Interact Cardiovasc Thorac Surg 2013; 16(6): 872-874.
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2018 Issue 3
Most read in this issue
- Intraoperative consultation in gynecologic pathology
- Molecular methods for detection of prognostic and predictive markers in diagnosis of adenoid cystic carcinoma of the salivary gland origin
- Aberrant axillary breast tissue with pseudoangiomatous stromal hyperplasia in a man
- Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value