Giant-cell lesions of bone and their differential diagnosis
Authors:
C. Povýšil
Authors‘ workplace:
Ústav patologie 1. LF UK a VFN v Praze
Published in:
Čes.-slov. Patol., 48, 2012, No. 3, p. 141-145
Category:
Reviews Article
Overview
Giant-cell lesions of bone-neoplastic and reactive growths form a group of clinicopathological entities that differ in their behaviour and may present substantial problems in differential diagnosis. The presence of multinucleated giant cells of the osteoclast type, reactive osteoplasia and the formation of secondary aneurysmal cysts in many unrelated lesions of bone further complicates their classification. Clinicopathologic correlation of all findings, including the radiologic features and laboratory tests, is of paramount importance in reaching a correct diagnosis in this group of histologically overlapping entities. Malignant features can be identified in the primary and secondary conventional malignant giant cell tumours and in some types of osteosarcoma with a giant cell component.
Keywords:
giant-cell lesions of bone – giant-cell tumor – osteoclast – osteosarcoma
Sources
1. Lau YS, Sabokbar A, Gibbons CL, Giela H, Athanasou N. Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue. Hum Pathol 2005; 36(9): 945–54.
2. Bulough P. Orthopaedic pathology. Mosby: Edinburg.; 2004: 547 pages.
3. Dorfman HD, Czerniak B. Bone tumours. Mosby: St. Louis; 1998: 559–606.
4. Fletcher CDM, Unni KK, Mertens F. WHO classification of tumours. Pathology and genetics of tumours of soft tissue and bone. IARC Press: Lyon; 2002: 422 pages.
5. Matějovský Z, Povýšil C, Kolář J. Kostní nádory. Praha: Avicenum; 1988: 65–405.
6. Povýšil C. Histopathology and ultrastructure of tumours and tumour-like lesions of bone. Acta Univ Carol Med. Monographia CXVI. 1986. Universita Karlova, 204 pages.
7. Vigorita VJ. Orthopaedic pathology. Philadelphia. Lippincott Williams and Wilkinms; 1999: 253–274.
8. Oda Y, Tsuneyoshi M, Shinohara N. „Solid“ variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions. Cancer 1992; 70(11): 2642–2649.
9. Lee CH, Espinosa I, Jensen KC, Subramanian S, Zhu SX, Varma S et al. Gene expression profilig identifies p63 as a diagnostic marker for giant cell tumor of the bone. Modern Pathol 2008; 21: 531–539.
10. Kolář J, Kučera V, Povýšil C, Čáp V, Kužel J, Kupka K. Erdheim-Chester Disease. Rofo 1984; 141(6): 698–701.
11. Ismail FW, Shanmsudin AM, Wan Z, Daum SM, Samarendra MS. Ki-67 immunohistochemistry index in stage III giant cell tumor of the bone. J Exp Clin Cancer Res 2010; 29: 25–32.
12. Yanagisawa M, OkadaK, Tajino T, Torigoe T, Kakai A, Nashida I. A Clinicopathological study of giant cell tumor of small bones. Ups J Med Sci 2011; 116(4): 265–268.
13. BufalinoA, Carrera M, Carlos R, Coletta RD. Giant cell lesions in Noonan syndrome: case report and review of the literature. Head and Neck Pathol 2010; 4(2): 174–177.
14. Povýšil C, Matějovský Z, Zídková H, Trnka V. Agressivní chondroblastom. Acta Chir Ortoped Traumatol Czech 1993; 60(4): 232–236.
15. Povýšil C, Tomanová R, Matějovský Z. Muscle-specific actin expression in chondroblastomas. Hum Pathol 1997; 28: 316–320.
16. Solovev JN, Dominok GW, Csató Z, Kunde P, Schmidt-Peter P, Povýšil C, et al. Malignant fibrous histiocytoma of the bones. Beitr Orthop Traumatol 1983; 30 (10): 536–546.
17. Odell EW, Morgan PR. Biopsy pathology of the oral tissues. London. Chapman and Hall medical; 1998: 485 pages.
18. Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and genetics of head and neck tumours. IARC Press, Lyon 2005, 429 pages.
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2012 Issue 3
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