Authors: F. Fakan; L. Boudová; A. Skálová Authors‘ workplace: Šiklův patologicko-anatomický ústav, Lékařská fakulta Univerzity Karlovy a Fakultní nemocnice, Plzeň Published in: Čes.-slov. Patol., , 2003, No. 3, p. 96-101 Category:
Our study included 46 cases of B-chronic lymphocytic leukemia/small lymphocytic lymphoma(B-CLL/SLL), 25 mantle cell lymphomas (MCL), and 40 follicular lymphomas (FL). The lymphomaswere diagnosed according to current morphological, immunohistochemical, and in some casesmolecular-genetic criteria. The patterns of follicular dendritic cells (FDCs) were studied in paraffinsections using the anti CD21, anti CD23, and CNA.42 antibodies. The differences in stainingpatterns of FDCs among the studied lymphomas were statistically significant. The absence orsmall number of FDC clusters are typical of B-CLL/SLL, while FDC meshwork limited to peripheralparts of neoplastic follicles is characteristic for FL. In contrast, MCL is characterized byirregular FDC meshwork or by FDC clusters present in the centres of residual follicles. Thus, wehave demonstrated that the patterns of FDCs is an independent diagnostic feature for distinguishingbetween B-CLL, FL, and MCL.
Key words: B-cell lymphoma - follicular dendritic cells - diagnosis - immunohistochemistry
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