2p13-16 Amplification in Extranodal Diffuse Large B-cell Lymphoma withRapid Lethal Course Resistent to Chemotherapy: a Case Report
Authors:
K. Hušek 1; P. Peťovská 2; D. Procházková 3
Authors‘ workplace:
I. patologickoanatomický ústav MU, FN u sv. Anny, Brno 2Oddělení lékařské genetiky MU, FN u sv. Anny, Brno 3I. dětská interní klinika, FN Brno, pracoviště Dětská nemocnice, Brno
1
Published in:
Čes.-slov. Patol., , 2003, No. 3, p. 138-142
Category:
Overview
Comparative genomic hybridisation (CGH) allows to detect genetic abnormalities associated withpoor prognosis in subset of patients with diffuse large B-cell lymphoma (DLBCL). Amplification of2p13-16 represents an adverse genetic sign especially in extranodal DLBCL. In the present case,2p13-16 amplification was revealed by CGH in extranodal DLBCL. It was localized in the mesenteryand remained resistant to the chemotherapy (CHOP). A patient, 72-year-old female, died 10weeks after the diagnosis had been made. Rapid lethal course of the disease confirms pooroutlook for patients with 2p13-16 and supports a role of CGH as a sensitive method in prognosisfor patients with DLBCL.
Key words:
comparative genomic hybridization – 2p13-16 amplification – diffuse large B-cell lymphoma
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2003 Issue 3
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