Authors: D. Kodetová; A. Jirásek; J. Briner; E. Fales Authors‘ workplace: Hlavův 1. patologickoanatomický ústav 1. LF UK a VFN, Praha, vedoucí prof. MUDr. P. Miřejovský, DrSc. Ústav hematologie a krevní transfuze, Praha, ředitel MUDr. RNDr. P. Jarolím, DrSc. Institut für Pathologie, Universität Zürich, Switzerland, vedoucí prof Published in: Čes.-slov. Patol., , 1999, No. 1, p. 5-9 Category:
Progressive multifocal leucoencephalopathy is caused by infection with JC virus. The diseaseaffects patients with immunodeficiencies, hematologic diseases, and patients treated with radio-therapy. The disease is characterised by foci of demyelinisation with atypical astrocytes andoligodendrocytes. Oligodendrocytes contain typical intranuclear inclusions. Progressive multifo-cal leucoencephalopathy and its verification is presented in three cases. Two patients died ofprogression of a malignant neoplasm and the leucoencephalopathy was a complication of themalignancy. The third case was a biopsy specimen taken from the brain of a patient who receiveda renal transplant. The material of all patients was analysed by light and electron microscopy,and in situ hybridisation with a probe specific for JC virus. In situ hybridisation proved to be themost specific and a simple method to demonstrate the infection in all cases. It is useful in instan-ces in which the histologically detectable lesion is not characteristic, and in cells in which theconventional histologic methods fail to reveal the intranuclear inclusions of JC virus.
Key words: progressive multifocal leucoencephalopathy - in situ hybridisation
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