Guidelines for inherited thrombophilia testing in children

Czech version

Authors: Kateřina Zdráhalová ¹; Pavel Mazánek ²; Ester Zápotocká ¹; Jan Blatný ²
Authors‘ workplace: Klinika dětské hematologie a onkologie, Fakultní nemocnice Motol a Homolka, Praha ¹; Oddělení dětské hematologie a biochemie, Fakultní nemocnice Brno ²
Published in: Čes-slov Pediat 2026; 81 (3): 155-157.
Category: Guidelines
doi: https://doi.org/10.55095/CSPediatrie2026/028

Overview

Zdráhalová K, Mazánek P, Zápotocká E, Blatný J. Guidelines for inherited thrombophilia testing in children

The incidence of thromboembolic disease in childhood is low compared to the adult population. Thrombophilia refers to factors that increase the risk of developing thrombosis. The most important factors in the development of thrombosis in children are acquired, with central venous catheters being the leading cause. In contrast, inherited thrombophilias play only a minor role. Approved consensus guidelines based on published literature specify the indications for testing for inherited thrombophilias and the scope of such testing. Incorrectly indicated, performed, and/or interpreted testing may be misleading and potentially harmful.

Keywords:

testing – thrombophilia – indication – childhood – thrombosis – inherited thrombophilia

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