The human microbiome and kidney diseases in children

Czech version

Authors: J. Krajčír ¹; B. Piteková ¹; M. Chromek ²; Ľ. Podracká ¹
Authors‘ workplace: Detská klinika, Národný ústav detských chorôb a Lekárska fakulta Univerzity Komenského, Bratislava, Slovensko ¹; Jednotka detskej nefrológie, Detská nemocnica Astrid Lindgrenovej, Karolínska univerzitná nemocnica a Karolinska Inštitút, Štokholm, Švédsko ²
Published in: Čes-slov Pediat 2021; 76 (7): 382-391.
Category: Review

Overview

The microbiome is a complex structure consisting of all bacteria, viruses, fungi and other microorganisms which colonize the surfaces and mucous membranes of the human body. There exists a specific and symbiotic relationship between the microbiome and the human body, both sides can benefit greatly from this relationship. Alterations of the normal microbiome composition can lead to various pathological conditions. The kidneys and gut micriobiome both produce several molecules which can regulate each other’s function in a positive or negative way. Are human urine and the mucous membranes of our urinary tract really sterile as suggested by the Human Microbiome project? Is it possible that there is a connection between the composition of the intestinal microbiome and the development of urinary tract infections in children? The therapy using fecal microbial transplantation has great results in patients with Clostridium difficile gut infections, but can it regulate the course of urinary tract infections in humans, too?

Keywords:

Urinary tract infections – gut microbiome – urobiome – colorenal axis

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