Histamine intolerance in childhood – case reports from clinical praxis
Authors:
M. Kohútová; M. Jeseňák; Ľ. Jakušová; L. Šofranková; O. Petrovičová; L. Vávrová 1; P. Bánovčin
Authors‘ workplace:
Klinika detí a dorastu, Univerzitná nemocnica Martin, Jesseniova lekárska fakulta v Martine
Univerzita Komenského v Bratislave
; Oddelenie lekárskej genetiky, Onkologický ústav sv. Alžbety n. o., Bratislava
1
Published in:
Čes-slov Pediat 2017; 72 (5): 314-321.
Category:
Case Report
Overview
Histamine intolerance (hereinafter referred to as HIT) is a disease which belongs to food intolerance disorders. Only several studies aimed at histamine intolerance research have been carried out in paediatric environment. Reasons behind the development of HIT may be an excessive accumulation of histamine in organism and a disorder of metabolic degradation of histamine. The clinical picture of HIT consists of several non-specific signs and symptoms which are often similar to allergic reactions. HIT poses a diagnostic problem, as an effective diagnostic tool for HIT is unavailable. A frequently used clinical method is to determine activity and concentration of diamine oxidase (DAO) in serum and in biopsy sample from intestinal epithelium. It is also possible to apply molecular genetics examination of polymorphisms in gene for DAO. However, the stated types of examination function as additional information only, as they do not lead to confirmation or exclusion of the disease. Clinical diagnosis is usually determined by a positive response of patients to low histamine diet and by an extensive diagnostical exclusion of other diseases.
KEY WORDS:
histamine intolerance, infants, diamine oxidase, DAO, molecular genetics examination, low histamine diet
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2017 Issue 5
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