Authors: A. Steinerová 1; F. Stožický 2; M. Korotvička 1; J. Racek 3; F. Tatzber 4 Authors‘ workplace: Medika-Centrum a. s., Plzeň vedoucí MUDr. A. Steinerová 1; Dětská klinika LF UK a FN, Plzeň přednosta prof. MUDr. F. Stožický, DrSc. 2; Ústav klinické biochemie a hematologie LF UK a FN, Plzeň přednosta prof. MUDr. J. Racek, DrSc. 3; Reagenzien und Recycling, Klosterneuburg, Austria 4 Published in: Čes-slov Pediat 2006; 61 (9): 519-523. Category: Original Papers
Atherosclerosis has acquired the character of epidemic in our century. The acknowledged factors of atherosclerosis lately include the oxidation stress. Our workplace has been dealing with oxidation stress factors for more than 10 years. Since 1998 we noticed a high titer of AboxLDL antibodies in children, whose mothers could not practice breast-feeding and artificial nutrition based on cow’s milk was necessary. This paper demonstrates that the presence of beta-casein in cow’s milk is the cause of increased AboxLDL titer, especially the A1 variant of beta-casein. In the experiment in pigs, however, we have not demonstrated any association between the high titer of AboxLDL and the development of premature atherosclerosis.
Key words: suckling nutrition, oxidation stress, antibodies against oxLDL, beta-casein, betacasein variants, atherosclerosis risk
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