Apolipoproteins in Cherokee Children and Adolescents
P. R. Blackett
1; W. Wang
2; E. Quintana
3; P. Alaupovic
4; E. T. Lee
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Center for American Indian Health Research, College of Public Health, University of Oklahoma Health
1; Sciences Center, Oklahoma City, Oklahoma
2; WW Hastings Indian Hospital, Tahlequah, Oklahoma
3; Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
Center for American Indian Health Research, College of Public Health, University
4; of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Čes-slov Pediat 2006; 61 (9): 477-483.
Since American Indians are susceptible to type 2 diabetes and associated cardiovascular risk, we determined the prevalence of risk factors in relation to age so that the data might reveal early predictors and intervention targets. We studied 5–20 year-old Cherokee Indians, who are members of the largest Indian Nation in Oklahoma. When we studied those without diabetes, we found that apolipoprotein B, apoC-III bound to apoB and the apoB:A-I ratio increased in proportion to the fasting insulin resistance (HOMA-IR), whereas HDL-C, LpA-I and LpA-I:A-II decreased, particularly in boys during adolescence. Visceral fat measured as the waist circumference had a significant effect on the HDL lipoproteins and HDL-C. Lp(a) was lower than in other ethnic groups, but when elevated, the levels may compound cardiovascular risk.
General practitioner for children and adolescents