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Failure of Vaccination against Haemophilus Influenzae Type b


Authors: J. Táborská 1;  V. Gutová 2;  A. Koubová 1;  P. Pazdiora 3;  V. Lebedová 4
Authors‘ workplace: Infekční klinika Fakultní nemocnice, Plzeň přednostka MUDr. J. Táborská, PhD. 1;  Ústav imunologie a alergologie LF UK, Plzeň přednosta doc. MUDr. P. Panzner, CSc. 2;  Ústav epidemiologie LF UK, Plzeň vedoucí doc. MUDr. P. Pazdiora, CSc. 3;  Národní referenční laboratoř pro hemofilové nákazy, Centrum epidemiologie a mikrobiologie, SZÚ, Praha vedoucí MUDr. V. Lebedová 4
Published in: Čes-slov Pediat 2005; 60 (5): 288-292.
Category: Case Report

Overview

The authors present a case report of a 19-month child regularly vaccinated with three doses of the vaccine against invasive infections caused by Haemophilus influenzae type b (Hib). In spite of that the patient suffered from bacterial meningitis caused exactly by this microbial strain. The immunological examination demonstrated a deficiency of serum immunoglobulins IgA and IgG, which was probably the cause of insufficient production of antibodies against polyribosil-ribitolphosphate (PRP) antigen Hib after the vaccination and, also, the cause of the disease development. The problems in failure of vaccination against Hib are discussed.

Key words:
Haemophilus influenzae type b, vaccination, meningitis


Labels
Neonatology Paediatrics General practitioner for children and adolescents
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