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The Development of Acute Nonlymphoblastic Leukemia during Treatment of Other Malignanciesin Children


Authors: J. Čáp 1;  E. Kaiserová 1;  G. Kirschnerová 2;  O. Babušíková 3
Authors‘ workplace: Oddelenie detskej onkológie Detskej fakultnej nemocnice s poliklinikou, Bratislava vedúci doc. MUDr. E. Kaiserová, CSc. Oddelenie genetiky nádorov, Národný onkologický ústav, Bratislava vedúci RNDr. V. Zajac, CSc. Oddelenie imunológie nádorov, Ústav exper
Published in: Čes-slov Pediat 2004; (10): 503-507.
Category:

Overview

Among of the total number of 273 children with different malignancies treated at the Pediatric OncologicDepartment in a period of 10 years in 4 boys secondary nonlymphoblastic leukemia was observed. It occured in2 children with acute lymphoblastic leukemia after 4 and 30 months lasting complete remission and in one childwith non-Hodgkin's lymphoma of T-type after 21 months lasting remission. ANLL was also seen in a patient withosteosarcoma after 15 months of unsuccessful cytostatic, surgical and radiotherapeutic treatment. The possibilityof initial bilinear leukemia on one hand and the possible effect of the cytostatic therapy on the other hand, mainlyof epipodophyllotoxin, which was a part of the chemotherapy in 3 patients, as pathogenic factors of developing ofsecondary myeloid leukemia are discussed.

Key words:
primary malignancy, secondary acute nonlymphoblastic leukemia, karyotyping, immunophenotyping,epipodophyllotoxins

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Neonatology Paediatrics General practitioner for children and adolescents
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