Present Possibilities of Evaluating Drug Efficacy in Common Clinical Practice

Authors: T. Sechser
Authors‘ workplace: Pracoviště klinické farmakologie Centra diabetologie, Institut klinické a experimentální medicíny, Praha přednosta doc. MUDr. T. Sechser, CSc.
Published in: Čes-slov Pediat 2004; (10): 536-538.


The beginning of the century is under the sign of shifted evaluation of drugs efficacy. The randomized controlledstudy remains the gold standard for providing the methodically best evaluation of efficiency of therapeuticintervention. The possibilities of evaluating drug efficacy in both methodic and interpretation point of view arechanging with putting emphasis upon the need of data obtained in common clinical practice, being apparentlymost suited for drug categorization in the beginning of IVth postregistration phase. Retrospective studiesevaluating whole therapeutic interventions bring important information with immediate implication to commonpharmacotherapeutic practice.

Key words:
clinical efficacy, clinical effectiveness, post-registration evaluation, retrospective evaluations ofinterventions

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