Authors: J. Sýkora; R. Pomahačová; F. Stožický; J. Schwarz; J. Varvařovská Authors‘ workplace: Dětská klinika, FN a LF UK, Plzeň přednosta doc. MUDr. F. Stožický, DrSc. Published in: Čes-slov Pediat 2003; (8): 497-499. Category:
Insulin-like growth factor (IGF-1) is belived to play a key role in regulation of cell activity. IGF-1 levels aregreatly influenced by various factors, chronologic age, and sex.The aim of our study was to evaluate age-defined normative serum values in the pediatric population in childrenyounger than 2 years of age. A total of 87 otherwise healthy children (47 male, 36 female) aged 0 to 2 years wereenrolled. Serum IGF-1 determinations were performed by the IRMA method. Mean IGF-1 serum levels for boysyounger than 1 year of age were 113 ng/ml, SD 45 ng/ml, and for girls 75 ng/ml, SD 45 ng/ml. In the group ofchildren younger than 2 year of age, mean IGF-1 levels for boys were 110 ng/ml, SD 50 ng/ml, and for girls 122ng/ml, SD 66 ng/ml.Conclusion: Serum concentrations of IGF-1 in children younger than 2 years are promising as a means formonitoring of the response in young children, and may be a supplementary aid in describing individual changesin various diseases.
Key words: insulin-like growth factor-1, age-defined normative values, age 0 to 2 years
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