Authors: J. Sýkora; A. Malán 1; J. Záhlava 1; J. Varvařovská; F. Stožický Authors‘ workplace: Dětská klinika FN a LF UK, Plzeň, přednosta doc. MUDr. F. Stožický, DrSc. Oddělení nukleární medicíny FN, Plzeň, 1 primář MUDr. J. Záhlava Published in: Čes-slov Pediat 2002; (12): 685-689. Category:
H. pylori has been established as a cause of various gastroduodenal disorders. The role of H. pylori in thedevelopment of functional dyspepsia (NUD) and recurrent abdominal pain (RAP) in children is unclear. Gastricmotility disturbances are considered to be associated with dyspeptic symptoms. The objectives of the study wereto elucidate whether gastric emptying was altered in children with and without H. pylori infection with NUD.A total of 36 consecutive children with NUD (n = 36, female 19, male 17, range 7 - 18 years) were enrolled inthe study. All children underwent extensive check-up to exclude organic lesions, ultrasonography, gastroscopy,histologic examination, and standardized scintigraphic examination using a technetium-99m (99mTc) radiolabelledsolid meal, and gastric emptying was measured as t1/2 (time taken for half the labelled meal to be emptied fromthe stomach). The updated Sydney system was used to score the grade of chronic gastritis (0 - 3). H. pylori infectionwas determined by two biopsy - based methods.Results: 19 (52.7 %) patients (13.74 ± 3.41 years) were identified as having H. pylori, 17 (47.3 %) patients (13.54± 3.12 years) were negative for H. pylori. The difference between the mean ages of two groups with and withoutH. pylori was statistically insignificant as well as for sex. There was no difference in clinical symptoms between thetwo groups. Nodular gastritis was found in 10/19 (52.6 %) in H. pylori positive patients, and in 1/17 (5.8 %) H.pylori negative (p
Key words: H. pylori, non-ulcerative dyspepsia, gastric emptying, scintigraphy
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