Authors: M. Salzerová 1; Ľ. Podracká 1; T. Baltesová 1; A. Feketeová 1; H. Hrbková 2; M. Jarčušková 1; M. Hricová 1 Authors‘ workplace: Klinika detí a dorastu LF UPJŠ a FNsP, Košice, 1 prednostka prof. MUDr. Ľ. Podracká, CSc. Združená tkanivová banka LF UPJŠ a FNsP, Košice, 2 prednosta MVDR. J. Rosocha, CSc. Published in: Čes-slov Pediat 2002; (11): 619-623. Category:
Leptin is a protein hormone formed mainly in adipocytes and excreted by the kidneys. Hypoleptinaemia isassociated with a reduction of body fat percentage and is found in malnutrition and endurance sports. Hyperleptinaemiais found in patients with chronic renal insufficiency and in obese subjects. The authors examined ina group of 80 children (patients with chronic renal insufficiency, malnutrition, obesity and in a control group ofhealthy children) serum leptin concentrations and compared them with nutritional and anthropometric parameters(BMI, SD, BMI, albumin, prealbumin, transferrin). Significantly higher leptin values were recorded in obesechildren (p < 0.001) and in children with chronic renal insufficiency (CHRI) as compared with healthy children (p< 0.01). In healthy girls the leptin level was higher than in healthy boys (p < 0.01). Patients with CHRI had higherleptin levels than children after transplantation of the kidneys (p < 0.05). In the group of children with CHRI leptincorrelated with creatinaemia (r = 0.479, p < 0.01) and with anthropometric indicators SD BMI (r = 0.693, p
Key words: leptin, chronic renal insufficiency, obesity, childhood
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