Bone Mineral Density in Girls with Turner’s Syndrome Treated with Growth Hormone
Authors:
J. Zapletalová 1; J. Lebl 2; J. Venháčová 1; T. Kraina 3
Authors‘ workplace:
Dětská klinika LF UP a FN, Olomouc, 1 přednosta doc. MUDr. V. Mihál, CSc. Klinika dětí a dorostu 3. LF UK a FN Královské Vinohrady, Praha, 2přednosta doc. MUDr. J. Lebl, CSc. III. interní klinika LF UP a FN, Olomouc, 3přednosta prof. MUDr. V. Ščudla, CSc.
Published in:
Čes-slov Pediat 2001; (6): 334-339.
Category:
Overview
In two groups of girls with Turner’s syndrome before treatment with growth hormone (GH), during treatment and after its termination bone density (BMD) was examined by two-photon densitometry (DEXA, Lunar DPX-L, Lunar Corp.) in the area of L2-L4.In 20 prepubertal girls GH treatment was started at the age of 10.0 ± 1.4 years (mean ± SEM), bone age 8.4 ± 1.3 years. Before GH treatment the BMD z-score related to chronological age (BMD-CA) was significantly reduced (-1.75 ± 0.28), while the z-score related to bone age (BMD-BA) (-0.42 ± 0.19) and to height age (BMD-HA) (0.18 ± 0.13) was within the normal range. After two years of GH treatment an increase of the z-score of BMD-CA occurred to -0.59 ± 0.18 (p
Key words:
Turner’s syndrome, bone mineral density, growth hormone treatment
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2001 Issue 6
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