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Results of Assessment of Antibodies against Tissue Transglutaminase in Patients with CoeliacDisease


Authors: A. Kolek 1;  J. Mathonová 1;  Z. Heřmanová 2;  M. Tichý 3;  J. Drábek 2;  I. Gregar 4
Authors‘ workplace: Dětská klinika FN a LF UP, Olomouc, 1přednosta doc. MUDr. V. Mihál, CSc. Imunologický ústav FN a LF UP, Olomouc, 2přednosta doc. MUDr. E. Weigl, CSc. Ústav patologické anatomie FN a LF UP, Olomouc, 3přednosta prof. MUDr. J. Dušek, CSc. II. interní klinika
Published in: Čes-slov Pediat 2000; (3): 162-165.

Overview

The authors assessed in 118 patients simultaneously antibodies against tissue transglutaminase - tTGA(Mediphan Diagnostica, Germany) and endomysial antibodies - EMA (The Binding Site, Birmingham, GreatBritain). In 58 patients a bioptic examination of the mucosa of the small bowel was made. In 26 cases a normalmorphological finding was obtained and tTGA and EMA were positive in two patients. In 32 patients villousatrophy was found. tTGA was elevated in 30 patients and EMA in 31. The sensitivity of the EMA examination is96.8% and the tTGA examination in 93.7%. The specificity of the two examinations is 92.3%. In a group of 57samples where the presence of EMA was found tTGA was negative 53x. A correlation was found between theresults of tTGA and EMA estimations. The use of the ELISA method seems more suitable for p rocessing of a largernumber of samples, it is less laborious and does not depend on subjective evaluation.

Key words:
coeliac disease, antibodies against tissue transglutaminase, endomysial antibodies

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Neonatology Paediatrics General practitioner for children and adolescents
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