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Infantile Haemangiomas: a Dermatologist's Perspective


Authors: R. Faberová 1;  P. Arenberger 2;  Š. Čapková 3;  S. Polášková 4;  J. Štěrba 5;  J. Vokurková 6;  D. Prusíková 2;  H. Bučková 1
Authors‘ workplace: Dětské kožní oddělení Pediatrické kliniky FN Brno a LF MU, Brno přednosta prof. MUDr. Zdeněk Doležel, CSc. 1;  Dermatovenerologická klinika 3. LF UK a FN Královské Vinohrady, Praha přednosta prof. MUDr. Petr Arenberger, Dr. Sc., MBA 2;  Dermatologické oddělení pro děti, FN Motol Praha primářka MUDr. Štěpánka Čapková 3;  Poliklinika VFN Karlovo náměstí, Dětská kožní ambulance Dermatovenerologické kliniky 1. LF UK a VFN, Praha přednosta prof. MUDr. Jiří Štork, CSc. 4;  Klinika dětské onkologie FN Brno a LF MU, Brno přednosta prof. MUDr. Jaroslav Štěrba, Ph. D. 5;  Oddělení plastické chirurgie KDCHOT FN Brno a LF MU, Brno přednosta prof. MUDr. Ladislav Plánka, Ph. D. 6
Published in: Čes-slov Derm, 92, 2017, No. 5, p. 206-218
Category: Reviews (Continuing Medical Education)

Overview

Infantile hemangiomas (IH) are the most common benign tumors affecting 10–12% of infants with increased incidence in premature and immature female babies. There are three basic types – superficial, deep and mixed. Infantile hemangiomas are the result of vasculogenesis and angiogenesis dysregulation. IH differ in number, size and depth of skin and subcutaneous tissue invasion. Most hemangiomas (90%) do not require treatment, involution lasting several years occurs after intense growth phase in the first 5 to 6 months of life. In extensive segmental and deep hemagiomas growth activity persists even in the 2nd and 3rd year of life. Approximately 10 % of IH might cause serious complications. Treatment choice is individual and requires comprehensive approach. The choice is the non-selective betablocker propranolol administered at a dose of 2–3mg/kg/day for 6–7 months. Propranolol acts as a vasoconstrictor of IH capillaries, blocks vascular endothelial growth factor (VEGF) promoting vascular development and induces apoptosis (natural death of vascular cells). Treatment has to be performed in centres with experienced pediatric dermatologist, oncologist, cardiologist, radiologist and plastic surgeon. Propranolol treatment is reimbursed in 4 centres in the Czech Republic (Faculty Hospitals in Motol, Královské Vinohrady, Brno and Ostrava).

Key words:
infantile hemangiomas – epidemiology – pathogenesis – differential diagnosis – therapy


Sources

1. ÁBARZÚA-ARAYA, A., NAVARRETE-DECHENT, C. P., HEUSSER, F. et al. Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study. J. Am. Acad. Dermatol., 2014, 70, p. 1045–1049.

2. ADAMS, M. T., SALTZMAN, B., PERKINS, J. A. Head and neck lymphatic malformation treatment a systematic review. Otolaryngol. Head Neck Surg., 2010, 147, p. 627–639.

3. AHOGO, C., EZZEDINE, K., PREY, S. et al. Factors associated with the relapse of infantile haemangiomas in chidren treated with propranolol. Brit. J. Dermatol., 2013, 169, p. 1252–1256.

4. BAULAND, C. G., LUNING, T. H., SMIT et al. Untreated hemangiomas:growth pattern and residual lesions. Plastic. Reconstr. Surg., 2011, 127, p. 1643–1648.

5. BAUMAN, N. M., SHIN, J. J., OH, A. K. et al. Propranolol vs prednisonole for symptomatic proliferating infantile hemangiomas a randomized clinical trial. JAMA Otolaryngol. Head and Neck Surg., 2014,140, p. 323–330.

6. BLEI, F. Congenital lymphatic malformation. Ann. N. Y. Acad. Sci., 2008, 1131, p. 185–194.

7. BLEI, F., MCELHINELLY, D. B., GUARINI, A. et al. Infantile heamangiomas with unsually prolonged growth phase:a case series. Arch. Dermatol., 2014, 144, p. 1632–1637.

8. BREUER, J. M., DE GRAAF, M., BREUGEM, C. C. et al. Hypoglycemia as a result of propranolol during treatment of infantile hemangioma:a case report. Pediatr. Dermatol., 2011, 28, p. 169–171.

9. CHAMLIN, S. L., HAGGSTROM, A. N., DROLET, B. A. et al. Multicenter prospective study of ulcerated hemangiomas. J. Pediatr., 2007, 151, p. 684–689.

10. CHAN, H., MCKAY, C., ADAMS, S. et al. RCT of timolol maleate gel for superficial infantile hemangiomas in 5-24 week-olds. Pediatrics, 2013, 131, p. 1739–1747.

11. CHEN, T. S., EICHENFIELD, L. F., FRIEDLANDER, S. F. Infantile Hemangiomas:an Update on pathogenesis and therapy. Pediatrics, 2013, 131, p. 99–108.

12. DEL FRARI, L., DELARUE, A. Data on File (Pierre Fabre). Presented at World Congress od Pediatric Dermatology, Madrid 2013.

13. DROLET, B. A., FROMMELT, P. C., CHAMLIN, S. I. et al. Initiation and use propranolol for infantile hemangioma: report of a consensus konference. Pediatr., 2013, 131, p. 128–140.

14. DROLET, B. A., POPE, E., JUERN, A. M. et al. Gastrointestinal bleeding in infatile hemangioma: a complication of segmental, rather than multifocal infantile hemangiomas. J. Pediatr., 2012, 160, p. 1012–1016.

15. Faberová, R.: Hemangiomy u dětí. Referátový výběr z dermatovenerologie, 2015, s. 11- 29.

16. Faberová, R., Bučková, H., Feit, J.: Hemangiomy u dětí. Čes-slov. Derm., 2002, 77, č. 4, s. 178-182, ISSN 0009-0514.

17. FABEROVÁ, R., PROCHÁZKA, J., CHARVÁTOVÁ, M. Nové poznatky léčby hemangiomů u dětí, jejich diferenciální diagnostika. Dermatol. pro praxi, 2009, 3, p. 75–77.

18. FABEROVÁ, R. Diagnostické přístupy a terapeutické možnosti periferních cévních anomálií u dětí. Disertační práce, 2003.

19. FEIT, J. Atlas dermatopatologie. Dostupné na www.atlases.muni.cz, 2003.

20. FIILLIPI, L., CAVALLARO, G., BAGNOLI, P. et al. Oral propranolol for retinopathy of prematurity: risks, safety concens, and perspectivex. J. Pediatr., 2013, 163, p. 1570–1577.

21. FLETCHER, D. CH. M., UNNI, K., MERTENS, F. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARCPress: Lyon 2002. ISBN 92 832 2413 2.

22. GIACHETTI, A., CARCIA-MONACO, R., SOJO, M. et al. Long-ter, tratment with oral propranolol reduces relapses of infantile hemangiomas. Pediatr. Dermatol., 2014, 31, p. 14–20.

23. GIRARD, C., BIGORRE, M., GUILLOT, B. et al. Pelvis syndrome. Arch. Dermatol., 2006, 142, p. 884–888.

24. GNARRA, M., SOLMAN, L., HARPER, J. I. et al. Propranolol and prednisolone combination for the tratment of segmental hemangioma in PHACES syndrome. Br. J. Dermatol., 2015, Doi:10.111/bjd.13588. Epub a head of print.

25. GREENBERGER, S., BISCHOFF, J. Pathogenesis of infantile hemangioma. Brit. J. Dermatol., 2013, 136, p. 12–19.

26. HACHISUGA, M., TSUKIMORI, K., HOJO, S. et al. Prenatal diagnosis of a retroperitoneal lymphangioma: a case and review. Fetal Diagnosis and Therapy, 2008, 24, p. 177–181.

27. HARPER, J. I. Neonatal haemangiomatosis associated with placental chorangiomas: report of three cases and review of the literature. Clin. Exp. Dermatol., 2009, 34:e78–80.

28. HENGST, M., OELERT, M., HOEGER, P. H. Blood pressure monitoring during the induction and maintenance period of propranolol therapy for complicated infantile hemangiomas. A prospective study of 109 infants. Pediatr. Dermatol., 2015.

29. HERMANS, D. J., BOEZEMAN, J. B., VAN DE KERKHOF, P. C. et al. Differences between ulcerated and non-ulcerated hemangioma:indications safety and future directions. Brit. J. Dermatol., 2009, 168, p. 152–156.

30. HERMANS, D. J., BAULAND, C. G., ZWEGGERS, J. et al. Propranolol in a case series of 174 patients with complicated infantile hemangioma: indications, safety and future directions. Brit. J. Dermatol., 2013, 168, p. 837–843.

31. HOEGER, PETER. H., HARPER, JOHN. I., BASELGA et al. Treatment of infantile haemangiomas: recommendations of a European expert group. Eur. J. Pediatr., May, 2015.

32. HOGELING, M., ADAS, S.,WARGON, O. A randomized controlled trial of propranolol for infantile hemangiomas. Pediatrics, 2011, 128, p. 259–266.

33. HOLLAND, K. E., FRIEDEN, I. J., FROMMELT, P. C. et al. Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch. Dermatol., 2010, 146, p. 775–777.

34. HURWITZ, S., PALLER, AMY. S., MANCINI et al. Clinical Pediatric Dermatology, A Textbook of Skin Disorders of Childhood and Adolescence. Third edition, 2006, p. 307–344. ISBN0323026117.

35. HURWITZ, S., PALLER, AMY. S. et al. Clinical Pediatric Dermatology. A Textbook of Skin Disorders of Childhood and Adolescence. 4th edition 2011, p. 268–299, ISBN9781437704129.

36. HURWITZ, S., PALLER, AMY. S. et al. Clinical Pediatric Dermatology. A Textbook of Skin Disorders of Childhood and Adolescence.

5th edition 2015, p. 279–304, ISBN 9780323244756.

37. International Society for the Study of Vascular Anomalies. ISSVA classification of vascular anomalies. 2014.issva.org/classification.

38. KAGAMI, S., KUWANO, Y., SHIBATA, S. et al. Propranolol Propranolol is more effective than pulsed dye laser and cryosungery for infantile hemangiomas. Eur. J. Pediatr., 2013,172, p. 1521–1526.

39. KAYLANI, S., THEOS, A. J., PRESSEY, J. G. Treatment of infantile hemangiomas with sirolimus in patient with PHACE syndrome. Pediatr. Dermatol., 2013, 30, p. 194–197.

40. KLAUZOVÁ, K. Přehled laserů používaných v estetické dermatologii. Referátový výběr z dermatovenerologie, 2014, 6, p. 24–29.

41. LANGLEY, A., POPE, B. Propranolol and central nervous system function: potential implication for pediatric patients with infantile hemangiomas. Br. J. Dermatol., 2015, 172, p. 12–23.

42. LÉAUTÉ-LABRÈZE, C. Propranolol for severe hemangiomas of infancy. N. Engl. J. Med., 2008, 358, 24, p. 2649–265.

44. LÉAUTÉ-LABRÈZE, C., BOCCARA, O. Safety of Oral Propranolol for the Treatment of Infantile Hemangioma. A Systematic Review. Pediatrics, 2016, 2016 Oct., 138(4).

45. LÉAUTÉ-LABRÈZE, C., HARPER, J. I., HOGER, P. H. Infantile haemangioma. Published:12, January 2017. DOI:http://dx.doi.org/10.1016/S0140-6736(16)00645-0.

46. LÉAUTÉ-LABREZE, C., PREY, S., EZZEDINE, K. Infantile hemangioma: part I. Pathophysiology, epidemiology, clinical features, life cycle and associated structural abnormalities. J. Eur. Acad. Dermatol. Venereol., 2011, 25, p. 1245–1253.

47. LÉAUTÉ-LABREZE, C., PREY, S., EZZEDINE, K. Infantile hemangioma: part II. Risks, complications and treatment. J. Eur. Acad. Dermatol. Venereol., 2011, 25, p. 1254–1260.

48. LEBOIT, E. P., BURG, G., WEEDON, D. et al. Pathology and Genetics of Skin Tumours. IARCPress: Lyon 2006. ISBN 92 832 2414 0.

49. MALIŠ, J. Hemangiomy kojenců. Česká dermatovener., 2014, 4, 1, p. 7–13.

50. MALIŠ, J., STARÁ, V. et al. Betablokátory v léčbě hemangiomů dětského věku. Čes.-Slov. Ped., 2014, 69, 5, p. 274–282.

50. MARQUELING, A. L., OZA, V., FRIEDEN, I. J. et al. Propranolol and infantile hemangiomas four years later: a systematic review. Pediatr. Dermatol., 2013, 30, p. 182–191.

51. MARUANI, A., PIRAM, M., SIRINELLI, D. et al. Visceral and mucosal involvement in neonatal haemangiomatosis. J. Eur. Acad. Dermatol. Venereol., 2012, 26, p. 1285–1290.

52. MENAPACE, D., MITKOV, M.,TOWBIN, R. et al. The changing face of complicated infantile hemangioma treatment. Pediatr. Radiol., 2016, Oct., 46, 11, p. 1494–506.

53. METRY, D., FRIEDEN, I. J., HESS, C. et al. Propranolol use in PHACE syndrome with cervical and intracranial arterial anomalies: collective experience in 32 infants. Pediatr. Dermatol., 2013, 30, p. 71–89.

54. MUNDEN, A., BUTSCHEK, R., TOM, W. L. et al. Prospective study of infantile haemangiomas: incidence clinical characteristics and associacion with placental anomalie. Brit. J. Dermatol., 2014, 170, p. 907–913.

55. PARIKH, S., DARROW, D. H., GRIMMER, J. F. et al. Propranolol use for infantile hemangiomas. American Society of Pediatric Otolaryngology Vascular Anomalies Task Force Practice Patterns. JAMA Otol. Rhinol. Head Neck Surg., 2013, 139, p. 153–156.

56. RUTTGEN, K. B., SUMMERER, B., SCHNEIDER, J. et al. Cardiovascular and blood Glucose parameters in infants during propranolol intitiation for tratment of symplomatic infantile hemangiomas. Am. Otol. Rhinol. Laryngol., 2013, 122, p. 550–554.

57. SOLMAN, L., MURABIT, A., GNARRA, M. et al. Propranolol for infantile haemangiomas; single centre experience of 250 cases and proposed therapeutic protocol. Arch. Dis. Child., 2014, 99, p. 1132–1136.

58. SCHUPP, C. J., KLEBER, J. B., GUNTHER, P. et al. Propranolol therapy in 55 infants with infantile hemangioma: dosage, duration, adverse effects, and outcome. Pediatr. Dermatol., 2011, 28, p. 640–644.

59. STOCKMAN, A., BORALEVI, F., TAIEB, A. et al. Sacral syndrome spinal dysraphism, anogenital, cutaneous, renal and urologic anomalies, associeted with an angioma of lumbosacral localization. Dermatol., 2007, 214, p. 40–45.

60. ŠMUCLER, R. Vysoce efektivní léčba hlubokých hemangiomů a arteriovenózních malformací intralezionálním laserem. Referátový výběr z dermatovenerologie, 2015, 3, s. 29–35.

61. VERGINE, G., MARSCIANI, A., PEDINI, A. et al. Efficacy of propranolol tratment in thyroid dysfunction associated with severe infantile hepatic hemangioma. Horm. Res. Pediatr., 2012, 78, p. 256–260.

62. UEBELHOER, M., BOON, M. L., VIKKULA, M. Vascular Anomalies From Genetics toward Models for Therapeutic Trials. Cold Spring Harb. Perspect. Med., 2012, 2:a009688.

63. VREDENBORG, A. D., JANMOHAMED, S. R., DE LAAT, P. C. J. et al. Multiple cutaneous infantile haemangiomas and the risk of haemangioma. Brit. Dermatol., 2013, 169, p. 188–191.

64. ZHENG, WEI. J., ZHANG, L., ZHOU, Q. et al. A practical quide treatment of infantile hemangiomas of the head and neck. Int. J. Clin. Exp. Med., 2013, 6, p. 851–860.

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