Relation between Sensitization to Respiratory Allergens and Bronchial Asthma, Allergic Rhinitis and Further Parameters in Patients with Atopic Eczema


Authors: J. Čelakovská 1;  K. Ettlerová 2;  K. Ettler 1;  J. Vaněčková 3;  J. Bukač 3
Authors‘ workplace: Klinika nemocí kožních a pohlavních FN a LF UK Hradec Králové přednosta doc. MUDr. Karel Ettler, CSc. 1;  Ambulance klinické imunologie a alergologie, Hradec Králové vedoucí MUDr. Květuše Ettlerová 2;  Ústav lékařské biofyziky LF UK Hradec Králové přednosta doc. Ing. Josef Hanuš, CSc. 3
Published in: Čes-slov Derm, 90, 2015, No. 5, p. 191-196
Category: Pharmacologyand Therapy, Clinical Trials

Overview

A few reports demonstrate the relationship between IgE sensitization to aeroallergens in atopic dermatitis and other allergic diseases and parameters. The objective of this study is to evaluate, if there is a significant relationship between the sensitization to common aeroallergens in atopic dermatitis patients and the occurrence of asthma bronchiale, rhinitis, and other atopic parameters. Sensitization to dust, mites, animal dander, and bird feather was examined byskin prick test and specific IgE. The relationship of sensitization to these allergens and the occurrence of asthma bronchiale, rhinitis, duration of atopic dermatitis, family history, and onset of atopic dermatitis was evaluated. We examined 288 patients – 90 men and 198 women. According to our results, IgE sensitisation to animal dander, dust and mites may increase the risk of developing asthma or rhinitis. In patients with sensitization on the feathers of birds occurs significantly more frequently the onset of atopic eczema after the 5th year of life and in these patients no relationship to the positive family history of atopy has been found.

Key words:
atopic dermatitis – inhalant allergy – mites – dust – animal dander – feather – asthma bronchiale – rhinitis – onset of atopic dermatitis – duration of eczema – family history


Sources

1. ARLIAN, L., PLATTS-MILLS, T. The biology of dust mites and the remediation of mite allergens in allergic disease. J. Allergy Clin. Immunol., 2001, 107, 3 Suppl., p. 406–413.

2. ARSHAD, S. Does exposure to indoor allergens contribute to the development of asthma and allergy? Current Allergy and Asthma Reports, 2010, 10, 1, p. 49–55.

3. BAR-SELA, S., TEICHTAHL, H., LUTSKY, I. Occupational asthma in poultry workers. J. Allergy Clin. Immunol., 1984, 73, 2, p. 271–275.

4. BIEBER, T., CORK, M., REITAMO, S. Atopic dermatitis: a candidate for disease-modifying strategy. Allergy, 2012, 40, p. 969–975.

5. BIEBER, T., LEUNG, D. In: Atopic dermatitis. Marcel Dekker, New York, 2002, p. 360.

6. BIEBER, T., LEUNG, D. In: Atopic dermatitis. Marcel Dekker, New York, 2002, p. 365.

7. BOGUNIEWICZ, M., LEUNG, D. Recent insights into atopic dermatitis and implications for management of infectious complications. J. Allergy Clin Immunol., 2010, 125, p. 4–13 (quiz 4–5).

8. BURGESS, J., WALTERS, E., BYRNES, G., MATHESON, M., JENKINS, M., WHARTON, C. ET AL. Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study. J. Allergy Clin. Immunol., 2007, 120, p. 863–869.

9. CALAMELLI, E., RICCI, G., NERI, I., RICCI, L., RONDELLI, R., PESSION, A., PATRIZI, A. Patterns of aeroallergen sensitization predicting risk for asthma in preschool children with atopic dermatitis. J. Asthma, 2015, 52, 5, p.458–464.

10. CARLSTEN, C., DIMICH-WARD, H., FERGUSON, A., WATSON, W., ROUSSEAU, R., DYBUNCIO, A. ET AL. Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors. Ann. Allergy Asthma Immunol., 2013, 110, p. 24–28.

11. CUSTOVIC, A., SIMPSON, A., WOODCOCK, A. Importance of indoor allergens in the induction of allergy and elicitation of allergic disease. Allergy, 1998, 53, 48 Suppl., p. 115–120.

12. GEHRING, U., HEINRICH, J., JACOB, B., RICHTER, K., FAHLBUSCH, B., SCHLENVOIGT, G., BISCHOF, W., WICHMANN, H. Indoor Factors and Genetics in Asthma (INGA) Study Group Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. Indoor Factors and Genetics in Asthma (INGA) Study Group. Eur. Respir. J., 2001, 18, 3, p. 555–563.

13. GENT, J., BELANGER, K., TRICHE, E., BRACKEN, M., BECKETT, W., LEADERER, B. Association of pediatric asthma severity with exposure to common household dust allergens. Environ Res., 2009, 109, 6, p. 768–774.

14. HANIFIN, J, RAJKA, G. Diagnostic features of atopic dermatitis. Acta Derm. Venereol., 1980, 92, p. 44–47.

15. HARRIS, J., WILLIAMS, H., White, C. ET AL. Early allergen exposure and atopic eczema. Br. J. Dermatol., 2007, 156, p. 698–704.

16. HOWELL, M., KIM, B., GAO, P., GRANT, A., BOGUNIEWICZ, M., DEBENEDETTO, A. ET AL. Cytokine modulation of atopic dermatitis filaggrin skin expression. J. Allergy Clin. Immunol., 2007, 120, p. 150–155.

17. KIM, B., LEUNG, D., BOGUNIEWICZ, M., HOWELL, M. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin. Immunol., 2008, 126, p. 332–337.

18. KUNZ, B., ORANJE, A., LABRÉZE, L., STALDER, J., RING, J., TAIEB, A. Clinical validation and guidelines for the SCORAD index: consensus report of the European task Force on Atopic Dermatitis. Dermatology, 1997, 195, 1, p. 10–19.

19. LEUNG, D., BIEBER, T. Atopic dermatitis. Lancet, 2003, 361, p. 151–160.

20. LEYNAERT, B., NEUKIRCH, C., KONY, S., GUENEGOU, A., BOUSQUET, J., AUBIER, M. ET AL. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J. Allergy Clin. Immunol., 2004, 113, p. 86–93.

21. PALMER, C., IRVINE, A., TERRON-KWIATKOWSKI, A., ZHAO, Y., LIAO, H., LEE, S. ET AL. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet., 2006, 38, p. 441–446.

22. RICCI, G., DONDI, A., NERI, I., RICCI, L., PATRIZI, A., PESSION, A. Atopic dermatitis phenotypes in childhood. Ital. J. Pediatr., 2014, 40, p. 46.

23. RICCI, G., PATRIZI, A., BALDI, E., MENNA, G., TABANELLI, M., MASI, M. Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases. J. Am. Acad. Dermatol., 2006, 55, p.765–771.

24. RICCI, G., PATRIZI, A., GIANNETTI, A., DONDI, A., BENDANDI, B., MASI, M. Does improvement management of atopic dermatitis influence the appearance of respiratory allergic diseases? A follow-up study. Clin. Mol. Allergy, 2010, 8, p. 8.

25. RING, J., PRZYBILLA, B., RUZICKA, T. Handbook of Atopic eczema. Springer-Verlag, Berlin/Heidelberg/New York. ISBN 3: 540-23133-1.

26. SCALABRIN, D., BAVBEK, S., PERZANOWSKI, M., WILSON, B., PLATTS-MILLS, T., WHEATLEY, L. Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. J. Allergy Clin. Immunol., 1999, 104, 6, p. 1273–1279.

27. SCHÄFER, T. The impact of allergy on atopic eczema from data from epidemiological studies. Curr. Opin. Allergy Clin. Immunol., 2008, 8, p. 418–422.

28. SCHÄFER, T., STIEGER, B., POLZIUS, R., KRAUSPE, A. Association between cat keeping, allergen exposure, allergic sensitisation and atopic diseases: results from the Children of Lübeck Allergy and Environment Study (KLAUS). Pediatr. Allergy Immunol., 2009, 20, p. 353–357.

29. SMALLWOOD, J., OWNBY, D. Exposure to dog allergens and subsequent allergic sensitization: an updated review. Curr. Allergy Asthma Rep., 2012,12, 5, p. 424–428.

30. SPERGEL, J. Epidemiology of atopic dermatitis and atopic march in children. Immunol. Allergy Clin. North Am., 2010, 30, p. 269–280.

31. SWIDERSKA-KIEŁBIK, S., KRAKOWIAK, A., WISZNIEWSKA, M., DUDEK, W., KOWALCZYK, M., WALUSIAK-SKORUPA, J. ET AL. Workrelated respiratory symptoms in bird zoo-keepers-questionnaire data. Int. J. Occup. Med. Environ. Health, 2009, 22, 4, p. 393–399.

32. TANG, T. S., BIEBER, T., WILLIAMS, H. Does “autoreactivity” play a role in atopic dermatitis? J. Allergy Clin. Immunol., 2012, 129, p. 1209–1215.

33. TAUER-REICH, I., FRUHMANN, G., CZUPPON, A., BAUR, X. Allergens causing bird fancier’s asthma. Allergy, 1994, 49, p. 448–453.

34. THOMAS, W., SMITH, W., HALES, B., MILLS, K., O’BRIEN, R. Characterization and immunobiology of house dust mite allergens. Int. Arch. Allergy Immunol., 2002, 129, p. 1–18.

35. TUPKER, R., DE MONCHY, J., COENRAADS, P. ET AL. Induction of atopic dermatitis by inhalation of house dust mite. J. Allergy Clin. Immunol., 1996, 97, p.1064–1070.

36. VALENTA, R., MITTERMANN, I., WERFEL, T., GARN, H., RENZ, H. Linking allergy to autoimmune disease. Trends Immunol., 2009, 30, p. 109–116.

37. VAN DEN OORD RA, SHEIKH A. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis. BMJ, 2009, 339, p. b2433.

38. VAN DER HULST, A., KLIP, H., BRAND, P. Risk of developing asthma in young children with atopic eczema: a systematic review. J. Allergy Clin. Immunol., 2007, 120, p. 565–569.

39. WAN, H., WINTON, H., SOELLER, C., TAYLOR, G., GRUENERT, D., THOMPSON, P. ET AL. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin. Exp. Allergy, 2001, 31, p. 279–294.

40. WAN, H., WINTON, H., SOELLER, C., TOVEY, E., GRUENERT, D., THOMPSON, P. ET AL. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J. Clin. Invest., 1999, 104, p. 123–133.

41. WEIDINGER, S., ILLIG, T., BAURECHT, H., IRVINE, A. D., RODRIGUEZ, E., DIAZ-LACAVA, A. ET AL. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J. Allergy Clin. Immunol., 2006, 118, p. 214–219.

42. WISNIEWSKI, J. AGRAWAL, R., MINNICOZZI, S., XIN, W., PATRIE, J., HEYMANN, P., WORKMAN, L., PLATTS-MILLS, T., SONG, T., MOLONEY, M., WOODFOLK, J. Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. Clin. Exp. Allergy, 2013, 43, 10, p. 1160–1170.

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