Cutaneous Manifestations in Dialysed Patients with Chronic Renal Failure

Authors: M. Kumpová 1;  P. Cetkovská 1;  S. Opatrná 2
Authors‘ workplace: Dermatovenerologická klinika FN a LF UK Plzeň 1;  I. interní klinika FN Plzeň přednosta prof. MUDr. Karel Pizinger, CSc. 2
Published in: Čes-slov Derm, 83, 2008, No. 5, p. 259-264
Category: Clinical and laboratory Research


Assessment of skin changes and characteristics of pruritus in patients with chronic renal failure.

The project consisted of clinical check-up and questionnaire focused on pruritus and skin changes.

In total, 58% of patients experienced pruritus that appeared prior to initiation of dialysis in 27% of them. In 15 % of patients the pruritus was generalized. The same percent reported on pruritus-associated sleep disorders. Analysis of pruritus according to method of dialysis and presence of diabetes mellitus did not reveal significant differences. Pruritus intensity was not dependent on the length of dialysis. In patients with antipruriginous therapy with antihistamines and emollients the treatment was successful in 70% of diabetic patients and in 74% of non-diabetics. Other cutaneous manifestations included skin dryness (87%), elastosis (67%), fungal, bacterial or viral infections (58%), pallor (51%), bruising/ecchymoses (41%), pigmentation (28%), worsened wound healing (28%), ichtyosiform scaling (26%), macroglossia (22%), skin lesions clinically suspicious of malignancy (8%), half-and-half nails (5%), bullous dermatoses (5%), prurigo nodularis (2%), calcifications (1%), gynecomastia (1%), and perforating disorders (1%).

Chronic renal failure is associated with numerous skin changes with great impact on patient quality of life. Regular dermatological examination to reveal present skin abnormalities and following medical intervention are therefore desirable.

Key words:
chronic renal failure – dialysis – pruritus


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