Medical, legal and etical aspects of fertility preservation in cancer survivor

Czech version

Authors: J. Záhumenský ¹; E. Kučera ¹; T. Kosová ²; J. Zmrhal ¹; M. Stejskal ²; D. Stejskal ²
Authors‘ workplace: Gynekologicko-porodnická klinika 3. LF UK a FN KV, přednosta doc. MUDr. E. Kučera, Ph. D. ¹; Centrum lékařské genetiky a reprodukční medicíny GENNET, Praha ²
Published in: Ceska Gynekol 2012; 77(2): 163-166
Category: Original Article

Overview

In recent years the number of the young women in fertile age which are oncologically treated is increasing. For these women chemotherapy and radiotherapy introduces potential risk of reproductive dysfunctions. Present techniques of assisted reproduction are offering possibilities to save reproductive functions even after the oncological treatment. As a perspective outlook seems to be frozen premature oocytes with IVM and fertilisation. With these fertility savings methods are naturally coming up some of the ethical and legal issues.

Key words:
cancer therapy, fertility, asisted reproduction, in vitro maturation.

Sources

1. Jemal, A., Siegel, R., Xu, J., Ward, E. Cancer statistics, 2010. CA Cancer J Clin, 2010, 60, 5, p. 277–300.

2. Henderson, TO., Friedman, DL., Meadows, AT. Childhood cancer survivors: transition to adult-focused risk-based care. Pediatrics, 2010, 126, 1, p. 129–136.

3. Schovej, LR., Rybicki, LA., Martin, BA., Bringelsen, KA. Having children after cancer. A pilot survey of survivors’ attitudes and experiences. Cancer, 1999, 86, 4, p. 697–709.

4. Schovej, LR., Brey, K,, Lichtin, A., et al. Oncologists’ attitudes and practices regarding banking sperm before cancer treatment. J Clin Oncol, 2002, 20, 7, p. 1890–1897.

5. Donnez, J., Martinez-Madrid, B., Jadoul, P., et al. Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update, 2006, 12, 5, p. 519–535.

6. Donnez, J., Dolmans, MM. Preservation of fertility in females with haematological malignancy. Br J Haematol, 2011, 154, 2, p. 175–184.

7. Wallace, WH., Thomson, AB., Saran, F., Kelsey, TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys, 2005, 62, 3, p. 738–744.

8. Wallace, WH., Stalet, SM., Hendry, JH., et al. Ovarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte. Br J Radiol, 1989, 62, 743, p. 995–998.

9. Chemaitilly, W., Mertens, AC., Mitry, P., et al. Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab, 2006, 91, 5, p. 1723–1728.

10. Green, DM., Sklar, CA., Boice, JJ., et al. Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. J Clin Oncol, 2009, 27, 14, p. 2374–2381.

11. Sklar, C. Reproductive physiology and treatment-related loss of sex hormone production. Med Pediatr Oncol, 1999, 33, 1, p. 2–8.

12. Sarafoglou, K., Soulad, F., Gillio, A., Sklar, C. Gonadal function after bone marrow transplantation for acute leukemia during childhood. J Pediatr, 1997, 130, 2, p. 210–216.

13. Shah, AJ. Successful pregnancy after busulfan/cytoxan conditioning regimen for AML. J Pediatr Hematol Oncol, 2011, 33, 5, p. e180–181.

14. Byrne, J. Infertility and premature menopause in childhood cancer survivors. Med Pediatr Oncol, 1999, 33, 1, p. 24–28.

15. Sklar, CA., Mertens, AC., Mitry, P., et al. Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Cancer Indy, 2006, 98, 13, p. 890–896.

16. Rienzi, L., Romano, S., Albricci, L., et al. Embryo development of fresh ‘versus’ vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study. Hum Reprod, 2010, 25, 1, p. 66–73.

17. Riggs, R., Mayer, J., Dowling-Lacey, D., et al. Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos. Fertil Steril, 2010, 93, 1, p. 109–115.

18. Neruse, JS., Woodruff, TK. Preservation of fertility in patients with cancer. N Engl J Med, 2009, 360, 9, p. 902–911.

19. Smith, GD., Serafini, PC., Fioravanti, J., et al. Prospective randomized comparison of human oocyte cryopreservation with slow-rate freezing or vitrification. Fertil Steril, 2010, 94, 6, p. 2088–2095.

20. Chian, RC., Juany, JY., Tan, SL., et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online, 2008, 16, 5, p. 608–610.

21. Oktay, K., Cil, AP., Bang, H. Efficiency of oocyte cryopreservation: a meta-analysis. Fertil Steril, 2006, 86, 1, p. 70–80.

22. Chian, RC., Juany, JY., Gilbert, L., et al. Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes. Fertil Steril, 2009, 91, 6, p. 2391–2398.

23. Oktay, K., Nugent, D., Newton, H., et al. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertil Steril, 1997, 67, 3, p. 481–486.

24. Donnez, J., Silber, S., Andersen, CY., et al. Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births. Ann Med, 2011, 43, 6, p. 437–450.

25. Mok-Lin, E., Missmer, S., Berry, K., et al. Public perceptions of providing IVF services to cancer and HIV patients. Fertil Steril, 2011, 96, 3, p. 722–727.

26. Temkin, E. Driving through: postpartum care during World War II. Am J Public Health, 1999, 89, 4, p. 587–595.

27. Kelly, JF. Deploying soldiers put family plans on ice. Washington Post 2003, p. B1, B2.

28. Informed consent, parental permission, and assent in pediatric practice. Committee on Bioethics, American Academy of Pediatrics. Pediatrics, 1995, 95, 2, p. 314–317.

29. Kuther, TL. Medical decision-making and minors: issues of consent and assent. Adolescence, 2003, 38, 150, p. 343–358.

30. Robertson, JA. Procreative liberty and harm to offspring in assisted reproduction. Am J Law Med, 2004, 30, 1, p. 7–40.

31. Campo-Engelstein, L. Consistency in insurance coverage for iatrogenic conditions resulting from cancer treatment including fertility preservation. J Clin Oncol, 2010, 28, 8, p. 1284–1286.

32. Pennings, G., de Wert, G., Shenfield, F., et al. ESHRE Task Force on Ethics and Law 11: Posthumous assisted reproduction. Hum Reprod, 2006, 21, 12, p. 3050–3053.