Acebutolol inthe Treatment of Arterial Hypertension during Pregnancy:Comparison with Commonly Used Antihypertensive Drugs

Overview

Objective:
The main purpose of our study was to analyse efficacy and safety of acebutolol (Sectral)in the treatment of hypertension in pregnancy.Design: Cohort clinical study comparing efficacy and safety of acebutolol with other antihypertensive drugs by 77 patients and their 81 new-borns. The number of 48 patients were treated byacebutolol.Setting: Internal Medicine and Clinical Pharmacology Department, Regional Hospital, Nitra andThe Faculty of Health Service and Social Work, University of Trnava; Department of Gynaecologyand Obstetrics, Regional Hospital Nitra and The Faculty of Health Service and Social Work,University of Trnava; Institute of Pharmacology, The Faculty of Medicine, Komenského University, Bratislava; Environment, a.s. Nitra.Methods: During the period of 6 years our patients were divided into subgroups according to thetype of hypertension in pregnancy and the severity of the illness which was the basis for usedantihypertensive drugs. One of the topics of the study was to provide monitoring of adverseevents by mother and possible drug influence on their new-born has been evaluated by investigating the week of birth, weight and length of the newborn and evaluating of Apgar score.Results: In the subgroup of 48 women treated by acebutolol we have confirmed the efficacy andsafety of this antihypertensive drug without any clinically significant effect on the quality of lifeof their new-born and evaluating of Apgar score.Conclusion: With regard to the results of our clinical study we can consider acebutolol to beeffective and safe antihypertensive drug in the treatment of hypertension in pregnancy.

Key words:
hypertension in pregnancy, acebutolol, efficacy, safety