Antibiotic Prophylaxis of Infectious Complications ofCaesarean Sections - Prospective Study

Overview

Objective:
To verify the significance of Cefazolin administration to women who were indicated forcaesarean section.Setting: Department of Obstetrics and Gynecology, First Faculty of Medicine, Prague, Czechrepublic.Methods: Cefazolin was administered to 30 women with a patient history risk in a dose of 1 mg i.v.after ligation of the umbilical cord. The control group consisted of 30 women. Observed parame-ters: weight gain during pregnancy, indications for caesarean section, culture from the cervix andvagina prior to the caesarean section, culture from the amniotic fluid, culture from the 4 th daylochia, temperature curve, leucocyte count before and 4 days after the operation, complicationsafter the surgery, administration of antibiotics, and length of hospitalisation.Results: In the group with antibiotic prophylaxis, we observed a more favourable course of thetemperature curve and a smaller leucocyte count the fourth day after the surgery (p < 0.01), incomparison with the women without prophylaxis. The duration of hospitalisation in women withantibiotic prophylaxis was one day shorter and there was no occurence of febrile complicationsrequiring further antibiotic treatment.Conclusion: Cafazolin is advantageous antibiotic for prophylaxis in caesarean section in patientswith risk.

Key words:
prophylaxis, caesarean section, Cefazolin