TaqI A Polymorphism of the DRD2 Gene and Alcoholism in the Czech Republic

Authors: J. Kašparovská *;  H. Hříbková *;  R. Hloušková *;  M. Novotný ***;  K. Gláslová ***;  V. Šimek *;  V. Mikeš **;  P. Zvolský ***;  O. Šerý *
Authors‘ workplace: Přírodovědecká fakulta MU, Katedra srovnávací fyziologie živočichů a obecné zoologie, Laboratoř neurobiologie a molekulární psychiatrie, Brno, vedoucí katedry prof. RNDr. V. Šimek, CSc. * Přírodovědecká fakulta MU, Katedra biochemie, Brno, vedoucí katedry ***
Published in: Čes. a slov. Psychiat., , 2003, No. 1, pp. 5-9.


Since 1990 many studies dealing with the association of the TaqI A polymorphism of the DRD2gene with alcoholism and other psychic disorders were published. Controversial results of thesepapers led us to investigate the relationship between TaqI A polymorphism of the DRD2 gene andalcoholism in the Czech Republic. In this study 571 persons were included (280 alcoholics and 291controls). The diagnostic criteria DSM-IV and ICD-10 for the diagnosis of alcoholism were used.Genomic DNA from the blood using the commercial kit UltraClean Blood Spin kit (MoBio, USA)was isolated. PCR and RFLP were used for genotyping. We found the same frequency of the A1allele in alcoholic and controls (0,18). A statistically significant difference in the frequency of theA1 allele was observed between males and females in the control group (p = 0.038). No associationof the Taq1 A polymorphism to alcohol dependence in the Czech Republic was found.

Key words:
TaqI A polymorphism, DRD2, alcoholism, alcohol dependence, association.

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Addictology Paediatric psychiatry Psychiatry
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