Intended pharmacotherapeutical approaches of Alzheimer’s disease therapy


Authors: Jan Korábečný1 ,2;  Eva Hrubá 3;  Ondřej Soukup 2;  Filip Zemek 2;  Kamil Musílek 4;  Eugenie Nepovímová 1;  Katarína Špilovská 2;  Veronika Opletalová 1;  Kamil Kuča 5
Authors‘ workplace: Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické chemie a kontroly léčiv 1;  Univerzita obrany, Fakulta vojenského zdravotnictví, Katedra toxikologie, Hradec Králové 2;  Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, katedra farmakologie a toxikologie 3;  Univerzita Hradec Králové, Přírodovědecká fakulta, Katedra chemie 4;  Univerzita obrany, Fakulta vojenského zdravotnictví, Centrum pokročilých studií a Fakultní nemocnice Hradec Králové 5
Published in: Čes. slov. Farm., 2012; 61, 4-10
Category: Review Articles

Overview

Alzheimer’s disease is a progressive neurodegenerative disorder mainly manifested by memory loss, personality changes, and cognitive dysfunction. Despite the fact that tireless research is being conducted, up-to-date pharmacotherapy of AD is presented only by two groups diverging in the mechanism of action. The larger one uses acetylcholinesterase inhibitors, and the second group is represented by the N-methyl-D-aspartate antagonist memantine. Even though the etiology of Alzheimer’s disease is unknown, several different therapeutic approaches are being investigated. The aim of this paper is to provide an overview of the present state of intended therapeutics for AD, describing their mechanism of action if known, displaying chemical structures, and the state of clinical trials if any.

Keywords:
Alzheimer’s disease • acetylcholinesterase • therapeutic approaches • beta amyloid • tau protein


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