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Clinical significance of cytochrome P450 genetic polymorphism – part III. cytochrome P450 2C19


Authors: Jana Ďuricová;  Milan Grundmann
Authors‘ workplace: Ústav klinické farmakologie Lékařské fakulty OU a FN Ostrava
Published in: Čes. slov. Farm., 2011; 60, 211-218
Category: Review Articles

Overview

Cytochrome P450 2C19 is the important cause for great differences in the pharmacokinetics of a number of clinically used drugs. Several studies have demonstrated that the CYP2C19 polymorphism is important for several drugs and may be associated with the occurrence of clinically relevant side effects. The third part of this paper focuses on the influence of genetic polymorphism of cytochrome P450 2C19 on drug effect.

Key words:
cytochrome P450 – genetic polymorphism – CYP2C19


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