Authors: M. Gápovský; M. Remko Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava Published in: Čes. slov. Farm., 2002; , 55-62 Category:
Leukotrienes are powerfizl mediators of inflammation processes. Possibilities of their biosynthesis inhibition have been intensively studied during recent two decades aiming to develop new methods of therapy of various inflammatory diseases, particularly asthma. Biosynthesis of all leukotrienes is dependent on the production of the key intermediate LTA4, Transformation of arachidonic acid to LTA4 is catalyzed by the enzyme 5-lipoxygenase and faciliated by FLAP. The present paper discusses the results of recent development of new drugs in this area.
Key words: leukotrienes - 5-lipoxygenase - inhibition of leukotriene synthesis - zileuton
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
