Authors: J. Čižmárik; J. Lehotay 1; A. Bednáriková 1; K. Hroboňová 1 Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava 1 Katedra analytickej chémie Chemickotechnologickej fakulty Slovenskej technickej univerzity, Bratislava 1 Published in: Čes. slov. Farm., 1999; , 276-280 Category:
On the basis of proposed six models of the dependence of local anaesthetic effectiveness of series ofalkoxysubstituted derivatives of phenylcarbamic acid, this activity was studies in dependence onthe capacity factor k’ as the parameter of lipophilicity. The most suitable models proved to be y =(Cx + Ci).k’ for surface anaesthesia, and y = Cx + Ci log k’ for infiltration anaesthesia, y being thevalue of the decadic logarithm of surface or infiltration local anaesthetic activity, Cx the coefficientcharacterizing the nitrogenous base, Ci the coefficient characterizing the individual alkoxygroups,and k’ the capacity factor from HPLC.
Key words: local anaesthetic activity – derivatives of alkoxyphenylcarbamic acid – capacityfactor k’ – dependence
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