In vitro Effect of Quinolones on Hydrophobicity of Acinetobacter baumannii

Czech version

Authors: A. Hoštacká
Authors‘ workplace: Ústav preventívnej a klinickej medicíny, Bratislava
Published in: Čes. slov. Farm., 1999; , 272-275
Category:

Overview

Effects of subinhibitory concentrations (sub-MICs) (1/4, 1/8, 1/16 or 1/32 of the MICs) of fourquinolone antibiotics on surface hydrophobicity of two Acinetobacter baumannii strains (R1 and R2)were tested. Hydrophobicity was evaluated by adherence of bacteria to xylene and their aggregationin ammonium sulphate solutions. Norfloxacin in concentrations of 1/4 or 1/8 of the MIC decreasedhydrophobicity of R1 strain and of R2 strain in concentration of 1/16 of the MIC. Ciprofloxacin wasefficient for both strains mainly in concentration of 1/4 of their MICs. Enoxacin (1/8 MIC) moreeffectively reduced hydrophobic properties only in R2 strain. The other concentrations of theabove-mentioned antibiotics as well as all tested concentrations of pefloxacin pract ically did notaffect bacterial surface hydrophobicity.

Key words:
quinolones – subinhibitory concentrations – Acinetobacter baumannii –surface hydrophobicity

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