Authors: E. Sedlárová; J. Čižmárik; Ľ. Búčiová Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava Published in: Čes. slov. Farm., 1999; , 170-174 Category:
The physico-chemical parameters (surface tension, dissociation constants, experimental partitioncoefficient, RF and RM values by means of thin-layer chromatography, logarithm of the capacityfactor with the help of HPLC) of 8 newly synthetic drugs from the group of 1-(4-phehyl-1-piperazi-nyl)-3-methoxy-2-propylesters of 2-, 3-alkoxyphenylcarbamic acids with assumed local anaesthetic,anti-arrhythmic, and antiulcerous activity were determined. The structure – physico-chemicalproperties relationship was investigated by means of QSAR.
Key words: 1-(4-phenyl-1-piperazinyl)-3-methoxy-2-propylesters of 2-, 3-alkoxyphenylcarbamicacids – physico-chemical properties – correlations
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