Significance and Limitations of Visual Evoked Potentials in the Study of Pathophysiology of Migraine


Authors: M. Bednář 1;  J. Kremláček 2,3;  Z. Kubová 2;  R. Taláb 4
Authors‘ workplace: Rehabilitační klinika LF UK a FN Hradec Králové 1;  Ústav patologické fyziologie LF UK v Hradci Králové 2;  Neurologická klinika LF UK a FN Hradec Králové 3;  LF UK v Hradci Králové 4
Published in: Cesk Slov Neurol N 2013; 76/109(2): 162-167
Category: Review Article

Overview

Dysfunction of the central nervous system is considered to be the primary factor in the pathophysiology of migraines. Neurophysiological techniques enable non-invasive testing of pathophysiological hypotheses of migraines. In this respect, Visual evoked potentials (VEP) are historically and currently the leading modality, even though the traditional assessment of VEP did not prove useful. Abnormal processing of visual information in migraines is de­monstrated by reduced or absent physiological decline in VEP amplitude (habituation deficit) during prolonged visual stimulation. This review article presents a selection of studies with VEP for migraine, including recent studies using neural excitability modulation (transcranial magnetic stimulation, hyperventilation and light deprivation). The findings from studies of habituation to VEP in migraines can support the theory of reduced preactivation thresholds of the cortex in the interictal period, based on the predominance of inhibitory mechanisms due to thalamo-cortical functional dissociation. However, migraine is characterized by cyclic changes in cortical activity – there is no VEP habituation deficit in preictal and ictal phases.

Key words:
visual evoked potentials – migraine – pathophysiology – habituation


Sources

1. Welch KM, D’Andrea G, Tepley N, Barkley G, Ramadan NM. The concept of migraine as a state of central neuronal hyperexcitability. Neurol Clin 1990; 8(4): 817–828.

2. Thompson RF. Habituation: a history. Neurobiol Learn Mem 2009; 92(2): 127–134.

3. Kuba M. Motion-onset visual evoked potentials and their diagnostic applications. Hradec Králové: Nucleus 2006.

4. Stejskal J et al. Evokované odpovědi a jejich klinické využití. Praha: Praga Publishing 1993.

5. Kubova Z, Kuba M, Spekreijse H, Blakemore C. Contrast dependence of motion-onset and pattern-reversal evoked potentials. Vision Res 1995; 35(2): 197–205.

6. Bartel PR, Vos A. Induced refractive errors and pattern electroretinograms and pattern visual evoked potentials: implications for clinical assessments. Eletroencephalogr Clin Neurophysiol 1994; 92(1): 78–81.

7. Langrova J, Kuba M, Kremlacek J, Kubova Z, Vit F. Motion-onset VEPs reflect long maturation and early aging of visual motion-processing system. Vision Res 2006; 46(4): 536–544.

8. Omland PM, Nilsen KB, Sand T. Habituation measured by pattern reversal visual evoked potentials depends more on check size than reversal rate. Clin Neurophysiol 2011; 122(9): 1846–1853.

9. Szanyi J, Kuba M, Kremláček J, Chlubnová J, Waberžinek G. Elektrofyziologické nálezy u migrény. Cesk Slov Neurol N 2001; 64/97(6): 349–354.

10. Schoenen J, Ambrosini A, Sándor PS, Maertens de Noordhout A. Evoked potentials and transcranial magnetic stimulation in migraine: published data and viewpoint on their pathophysiologic significance. Clin Neurophysiol 2003; 114(6): 955–972.

11. Schoenen J, Wang W, Albert A, Delwaide PJ. Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks. Eur J Neurol 1995; 2(2): 115–122.

12. Afra J, Cecchini AP, De Pasqua V, Albert A, Schoenen J. Visual evoked potentials during long periods of pattern-reversal stimulation in migraine. Brain 1998; 121(2): 233–241.

13. Afra J, Cecchini AP, Sándor PS, Schoenen J. Comparison of visual and auditory evoked cortical poten­tials in migraine patients between attacks. Clin Neurophysiol 2000; 111(6): 1124–1129.

14. Wang W, Wang GP, Ding XL, Wang YH. Personality and response to repeated visual stimulation in migraine and tension-type headaches. Cephalalgia 1999; 19(8): 718–724.

15. Judit A, Sándor PS, Schoenen J. Habituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack. Cephalalgia 2000; 20(8): 714–719.

16. Ozkul Y, Bozlar S. Effects of fluoxetine on habituation of pattern reversal visually evoked poten­tials in migraine prophylaxis. Headache 2002; 42(7): 582–587.

17. Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V, Schoenen J. Nociceptive blink reflex and visual evoked potential habituations are correlated in migraine. Headache 2005; 45(10): 1388–1393.

18. Coppola G, Ambrosini A, Di Clemente L, Magis D, Fumal A, Gérard P et al. Interictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia? Cephalalgia 2007; 27(12): 1360–1367.

19. Coppola G, Currà A, Serrao M, Di Lorenzo C, Gorini M, Porretta E et al. Lack of cold pressor test-induced effect on visual-evoked potentials in migraine. J Headache Pain 2010; 11(2): 115–121.

20. Oelkers R, Grosser K, Lang E, Geisslinger G, Kobal G, Brune K et al. Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency. Brain 1999; 122(6): 1147–1155.

21. Sand T, Vingen JV. Visual, long-latency auditory and brainstem auditory evoked potentials in migraine: relation to pattern size, stimulus intensity, sound and light discomfort thresholds and pre-attack state. Cephalalgia 2000; 20(9): 804–820.

22. Schoenen J. Deficient habituation of evoked cortical potentials in migraine: a link between brain biology, behavior and trigeminovascular activation? Biomed Pharmacother 1996; 50(2): 71–78.

23. Afra J, Ambrosini A, Genicot R, Albert A, Schoenen J. Influence of colors on habituation of visual evoked potentials in patients with migraine with aura and in healthy volunteers. Headache 2000; 40(1): 36–40.

24. Bohotin V, Fumal A, Vandenheede M, Gérard P, Bohotin C, Maertens de Noordhout A et al. Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine. Brain 2002; 125(4): 912–922.

25. Boroojerdi B, Battaglia F, Muellbacher W, Cohen LG. Mechanism underlying rapid experience-dependent plasticity in the human visual cortex. Proc Natl Acad Sci U S A 2001; 98(25): 14698–14701.

26. Palermo A, Giglia G, Vigneri S, Cosentino G, Fierro M, Brighina F. Does habituation depend on cortical inhibition? Results of an rTMS study in healthy subjects. Exp Brain Res 2011; 212(1): 101–107.

27. Coppola G, Crémers J, Gérard P, Pierelli F, Schoenen J. Effects of light deprivation on visual evoked potentials in migraine without aura. BMC Neurol 2011; 11: 91.

28. Coppola G, Currà A, Sava SL, Alibardi A, Parisi V, Pierelli F et al. Changes in visual-evoked potential habituation induced by hyperventilation in migraine. J Headache Pain 2010; 11(6): 497–503.

29. Coppola G, Serrao M, Currà A, Di Lorenzo C, Vatrika M, Parisi V et al. Tonic pain abolishes cortical habituation of visual evoked potentials in healthy subjects. J Pain 2010; 11(3): 291–296.

30. Kremlacek J, Kuba M, Kubova Z, Langrova J, Vit F, Szanyi J. Within-session reproducibility of motion-onset VEPs: effect of adaptation/habituation or fatique on N2 peak amplitude and latency. Doc Ophtalmol 2007; 115(2): 95–103.

31. Köseoglu E, Talaslioglu A, Gönül AS, Kula M. The effects of magnesium prophylaxis in migraine without aura. Magnes Res 2008; 21(2): 101–108.

32. Yilmaz H, Erkin EF, Mavioğlu H, Sungurtekin U. Changes in pattern reversal evoked poten­tials during menstrual cycle. Int Ophtalm 1998; 22(1): 27–30.

33. Yilmaz H, Erkin E, Mavioğlu H, Laçin S. Effects of oestrogen replacement therapy on pattern reversal visual evoked potentials. Eur J Neurol 2000; 7(2): 217–221.

34. Sándor PS, Afra J, Ambrosini A, Shoenen J. Prophylactic treatment of migraine with beta-blockers and riboflavin: differential effects on the intensity dependence of auditory evoked cortical potentials. Headache 2000; 40(1): 30–35.

35. Ambrosini A, Schoenen J. Electrophysiological response patterns of primary sensory cortices in migraine. J Headache Pain 2006; 7(6): 377–388.

36. Coppola G, Pierelli F, Schoenen J. Habituation and migraine. Neurobiol Learn Mem 2009; 92(2): 249–259.

37. Stankewitz A, May A. The phenomenon of changes in cortical excitability in migraine is not migraine-specific – a unifying thesis. Pain 2009; 145(1–2): 14–17.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 2

2013 Issue 2

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account