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proLékaře.cz / Journals / Clinical Osteology / 2021 - 2

Pathophysiology of bone quality changes in obese diabetics

Czech version

Authors: Fröhlich Mária;  Jackuliak Peter;  Smaha Juraj;  Payer Juraj
Authors‘ workplace: V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
Published in: Clinical Osteology 2021; 26(2): 80-88
Category:

Overview

Diabetes mellitus (DM) and osteoporosis are the predominant diseases worldwide and are associated with significant prevalence, morbidity and mortality. The main goal of this work is to determine the importance of the association between type 2 diabetes mellitus (T2DM) and osteoporosis, as well as to confirm the possible negative effect on bone tissue and at the same time to prove changes in bone microarchitecture. Complications associated with diabetes may increase the risk of falls and thus adversely affect bone tissue, as well as DM treatment with antidiabetics and insulin alone may contribute to the alteration of bone material by either a direct or indirect mechanism. T2DM is often accompanied by obesity, which mediates its negative effect through inflammation and the release of adipokines. Early detection of the disease is key in the prevention and treatment of potential complications of bone changes. This article is divided into 8 sections, which deal with the diseases of diabetes mellitus and osteoporosis, their classification, etiopathogenesis, diagnosis and treatment. In the next part, we tried to evaluate the mechanism of action of T2DM on bone tissue.

Keywords:

bone tissue – diabetes mellitus – Osteoblasts – Osteocytes – Osteoclasts – osteoporosis – age

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