Neurogenic heterotopic ossification


Authors: Oc K Ján
Authors‘ workplace: Oddelenie ortopédie, FNsP J. A. Reimana Prešov
Published in: Clinical Osteology 2020; 25(3): 128-134
Category:

Overview

Neurogenic heterotopic ossification (NHO) is a complication affecting one in five patients after a spinal cord injury or traumatic brain injury. It leads to severe pain, loss of range of motion, as the joint gradually becomes ankylosed, leading to greater functional disability. The etiopathogenesis and risk factors of NHO remain poorly understood. The aim of this review was to focus on advances in the understanding of the underlying mechanisms of NHO, and possible options for the diagnosis, prevention and treatment of NHO.

Keywords:

heterotopic ossification – spinal cord injury – traumatic brain injury


Sources
  1. Brooker AF, Bowerman JW, Robinson RA et al. Ectopic ossification following total hip replacement. Incidence and method of classification. J Bone Joint Surg Am 1973; 55(8): 1629–1632.

  2. Garland DE. A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop 1991; (263): 13–29.

  3. Pignolo RJ, Kaplan FS. Clinical staging of fibrodysplasia ossificans progressiva (FOP). Bone 2018; 109: 111–114. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bone.2017.09.014>.

  4. Kaplan FS, Craver R, MacEwen GD et al. Progressive osseous heteroplasia: a distinct developmental disorder of heterotopic ossification. Two new case reports and follow-up of three previously reported cases. J Bone Joint Surg Am 1994; 76(3): 425–36.

  5. Cipriano CA, Pill SG, Keenan MA. Heterotopic ossification following traumatic brain injury and spinal cord injury. J Am Acad Orthop Surg 2009; 17(11): 689–697. Dostupné z DOI: <http://dx.doi.org/10.5435/00124635–200911000–00003>.

  6. van Kuijk AA, Geurts AC, van Kuppevelt HJ. Neurogenic heterotopic ossification in spinal cord injury. Spinal Cord 2002; 40(7): 313–326. Dostupné z DOI: <http://10.1038/sj.sc.3101309>.

  7. Vanden Bossche L, Vanderstraeten G. Heterotopic ossification: a review. J Rehabil Med 2005; 37(3): 129–136. <http://dx.doi.org/10.1080/16501970510027628>.

  8. Genêt F, Jourdan C, Schnitzler A et al. Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries. PloS One 2011; 6(1): e16632. Dostupné z DOI: <http://dx.doi.org/10.1371/journal.pone.0016632>.

  9. Halas RA, Karuppiah S. Heterotopic ossification of the hip after stroke. Curr Orthop Pract 2011; 22(2): E19–E21. Dostupné z DOI: <http://dx.doi.org/10.1097/BCO.0b013e3181ff73af>.

  10. Simonsen LL, Sonne-Holm S, Krasheninnikoff M et al. Symptomatic heterotopic ossification after very severe traumatic brain injury in 114 patients: incidence and risk factors. Injury 2007; 38(10):1146–1150. Dostupné z DOI: <http://dx.doi.org/10.1016/j.injury.2007.03.019>.

  11. Garland DE. Clinical observations on fractures and heterotopic ossification in the spinal cord and traumatic brain injured populations. Clin Orthop Relat Res 1988; (233): 86–101.

  12. Ebinger T, Roesch M, Kiefer H et al. Influence of etiology in heterotopic bone formation of the hip. J Trauma 2000; 48(6): 1058–1062. Dostupné z DOI: <http://dx.doi.org/10.1097/00005373–200006000–00010>.

  13. Garland DE, O’Hollaren RM. Fractures and dislocations about the elbow in the head-injured adult. Clin Orthop Relat Res 1982; (168): 38–41.

  14. Wittenberg RH, Peschke U, Bötel U. Heterotopic ossification after spinal cord injury: Epidemiology and risk factors. J Bone Joint Surg Br 1992; 74(2): 215–218.

  15. Scher AT. The incidence of ectopic bone formation in post-traumatic paraplegic patients of different racial groups. Paraplegia 1976; 14(3): 202–206. Dostupné z DOI: <http://dx.doi.org/10.1038/sc.1976.35>.

  16. Sundaram NA, Murphy JC. Heterotopic bone formation following total hip arthroplasty in ankylosing spondylitis. Clin Orthop Relat Res 1986; (207): 223–226.

  17. Larson JM, Michalski JP, Collacott EA et al. Increased prevalence of HLA-B27 in patients with ectopic ossification following traumatic spinal cord injury. Rheumatol Rehabil 1981; 20(4): 193–197. Dostupné z DOI: <http://dx.doi.org/10.1093/rheumatology/20.4.193>.

  18. Garland DE, Alday B, Venos KG. Heterotopic ossification and HLA antigens. Arch Phys Med Rehabil 1984; 65(9): 531–532.

  19. Mitchell EJ, Canter J, Norris P et al. The genetics of heterotopic ossification: insight into the bone remodeling pathway. J Orthop Trauma 2010; 24(9): 530–533. Dostupné z DOI: <http://dx.doi.org/10.1097/BOT.0b013e3181ed147b>.

  20. Pape HC, Lehmann U, van Griensven M et al. Heterotopic ossifications in patients after severe blunt trauma with and without head trauma: incidence and patterns of distribution. J Orthop Trauma 2001; 15(4): 229–237. Dostupné z DOI: <http://dx.doi.org/10.1097/00005131–200105000–00001>.

  21. Brighton CT, Schaffer JL, Shapiro DB et al. Proliferation and macromolecular synthesis by rat calvarial bone cells grown in various oxygen tensions. J Orthop Res 1991; 9(6): 847–854. Dostupné z DOI: <http://dx.doi.org/10.1002/jor.1100090610>.

  22. Miller LF, O’Neill CJ. Myositis ossificans in paraplegics. J Bone Joint Surg 1949; 31(A): 283–294.

  23. Rossier AB, Bussat P, Infante F et al. Current facts on para-osteo-arthropathy (POA). Paraplegia 1973; 11(1): 38–78. Dostupné z DOI: <http://dx.doi.org/10.1038/sc.1973.5>.

  24. Jensen LL, Halar E, Little JW et al. Neurogenic heterotopic ossification. Am J Phys Med 1987; 66(6): 351–363.

  25. Ackerman LV. Extra osseous localized non-neoplastic bone and cartilage formation. J Bone Joint Surg 1958; 40-A(2): 279–298.

  26. Peck RJ, Metreweli C. Early myositis ossificans: a new echographic sign. Clin Radiol 1988; 39(6): 586–588. Dostupné z DOI: <http://dx.doi.org/10.1016/s0009–9260(88)80052–7>.

  27. Chalmers J, Gray DH, Rush J. Observations on the induction of bone in soft tissues. J Bone Joint Surg 1975; 57(1): 36–45.

  28. Cadosch D, Toffoli AM, Gautschi OP et al. Serum after traumatic brain injury increases proliferation and supports expression of osteoblast markers in muscle cells. J Bone Joint Surg Am 2010; 92(3): 645–653. Dostupné z DOI: <http://dx.doi.org/10.2106/JBJS.I.00097>.

  29. Mastrogiacomo M, Derubeis AR, Cancedda R. Bone and cartilage formation by skeletal muscle derived cells. J Cell Physiol 2005; 204(2): 594–603. Dostupné z DOI: <http://dx.doi.org/10.1002/jcp.20325>.

  30. Gautschi OP, Cadosch D, Frey SP et al. Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg 2009; 79(6): 449–455. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1445–2197.2008.04803.x>.

  31. Castillo J, Rodríguez I. Biochemical changes and inflammatory response as markers for brain ischaemia: molecular markers of diagnostic utility and prognosis in human clinical practice. Cerebrovasc Dis 2004; 17(Suppl 1): 7–18. Dostupné z DOI: <http://dx.doi.org/10.1159/000074791>.

  32. Trentz OA, Handschin AE, Bestmann L et al. Influence of brain injury on early posttraumatic bone metabolism. Crit Care Med 2005; 33(2): 399–406. Dostupné z DOI: <http://dx.doi.org/10.1097/01.ccm.0000152221.87477.21>.

  33. Hohmann EL, Elde RP, Rysavy JA et al. Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers. Science 1986; 232(4752): 868–871. Dostupné z DOI: <http://dx.doi.org/10.1126/science.3518059>.

  34. Jones KB, Mollano AV, Morcuende JA et al. Bone and brain: a review of neural, hormonal, and musculoskeletal connections. Iowa Orthop J 2004; 24: 123–132.

  35. Argyropoulou MI, Kostandi E, Kosta P et al. Heterotopic ossification of the knee joint in intensive care unit patients: early diagnosis with magnetic resonance imaging. Crit Care 2006; 10(5): R152. Dostupné z DOI: <http://dx.doi.org/10.1186/cc5083>.

  36. Takeda S, Elefteriou F, Levasseur R et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002; 111(3): 305–317. Dostupné z DOI: <http://dx.doi.org/10.1016/s0092–8674(02)01049–8>.

  37. Gordeladze JO, Drevon CA, Syversen U et al. Leptin stimulates human osteoblastic formation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis and osteoclastic signaling. J Cell Biochem 2002; 85(4): 825–836. Dostupné z DOI: <http://dx.doi.org/10.1002/jcb.10156>.

  38. Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth Factors 2004; 22(4): 233–241. Dostupné z DOI: <http://dx.doi.org/10.1080/08977190412331279890>.

  39. Kang Q, Sun MH, Cheng H et al. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 2004; 11(17): 1312–1320. Dostupné z DOI: <http://dx.doi.org/10.1038/sj.gt.3302298>.

  40. Salisbury E, Rodenberg E, Sonnet C et al. Sensory nerve induced inflammation contributes to heterotopic ossification. J Cell Biochem 2011; 112(10): 2748–58. Dostupné z DOI: <http://dx.doi.org/10.1002/jcb.23225>.

  41. Kan L, Kitterman JA, Procissi D et al. CNS demyelination in fibrodysplasia ossificans progressiva. J Neurol 2012; 259(12): 2644–2655. Dostupné z DOI: <http://dx.doi.org/10.1007/s00415–012–6563-x>

  42. Shehab D, Elgazzar AH, Collier BD. Heterotopic ossification. J Nucl Med 2002; 43(3): 346–353.

  43. Schurch B, Capaul M, Vallotton MB et al. Prostaglandin E2 measurements: their value in the early diagnosis of heterotopic ossification in spinal cord injury patients. Arch Phys Med Rehabil 1997; 78(7): 687–691. Dostupné z DOI: <http://dx.doi.org/10.1016/s0003–9993(97)90074–5>.

  44. Orzel JA, Rudd TG. Heterotopic bone formation: clinical, laboratory, and imaging correlation. J Nucl Med 1985; 26(2): 125–32.

  45. Pistarini C, Carlevati S, Contardi A et al. Use of ultrasonography methods in the diagnosis of neurogenic paraosteoarthropathy in spinal cord injury. Recenti Prog Med 1995; 86(12): 483–488.

  46. Popken F, Konig DP, Tantow M et al. Possibility of sonographic early diagnosis of heterotopic ossification after total hip-replacement. Unfallchirurg 2003; 106(1): 28–31. Dostupné z DOI: <http://dx.doi.org/10.1007/s00113–002–0461–0>.

  47. Svircev JN, Wallbom AS. False-negative triple-phase bone scans in spinal cord injury to detect clinically suspect heterotopic ossification: a case series. J Spinal Cord Med 2008; 31(2): 194–196. Dostupné z DOI: <http://dx.doi.org/10.1080/10790268.2008.11760711>.

  48. Banovac K, Williams JM, Patrick LD et al. Prevention of heterotopic ossification after spinal cord injury with indomethacin. Spinal Cord 2001; 39(7): 370–374. <http://dx.doi.org/10.1038/sj.sc.3101166>.

  49. Banovac K, Williams JM, Patrick LD et al. Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib). Spinal Cord 2004; 42(12): 707–710. Dostupné z DOI: <http://dx.doi.org/10.1038/sj.sc.3101628>.

  50. Garland DE, Alday B, Venos KG et al. Diphosphonate treatment for heterotopic ossification in spinal cord injury patients. Clin Orthop 1983; (176): 197–200.

  51. Spielman G, Gennarelli TA, Rogers CR. Disodium etidronate: its role in preventing heterotopic ossification in severe head injury. Arch Phys Med Rehabil 1983; 64(11): 539–542.

  52. Banovac K. The effect of Etidronate on late development of heterotopic ossification after spinal cord injury. J Spinal Cord Med 2000; 23(1): 40–44. Dostupné z DOI: <http://dx.doi.org/10.1080/10790268.2000.11753507>.

  53. Balboni TA, Gobezie R, Mamon HJ. Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys 2006; 65(5): 1289–1299. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ijrobp.2006.03.053>.

  54. Seegenschmiedt MH, Keilholz L, Martus P et al. Prevention of heterotopic ossification about the hip: final results of two randomized trials in 410 patients using either preoperative or postoperative radiation therapy. Int J Radiat Oncol Biol Phys 1997; 39(1): 161–171. Dostupné z DOI: <http://dx.doi.org/10.1016/s0360–3016(97)00285-x>.

  55. Sautter-Bihl ML, Hultenschmidt B, Liebermeister E et al. Fractionated and single-dose radiotherapy for heterotopic bone formation in patients with spinal cord injury. A phaseI/II study. Strahlenther Onkol 2001; 177(4): 200–205. Dostupné z DOI: <http://dx.doi.org/10.1007/pl00002399>.

  56. Sautter-Bihl ML, Liebermeister E, Nanassy A. Radiotherapy as a local treatment option for heterotopic ossifications in patients with spinal cord injury. Spinal Cord 2000; 38(1): 33–36. Dostupné z DOI: <http://dx.doi.org/10.1038/sj.sc.3100847>.

  57. Genet F, Jourdan C, Lautridou C et al. The impact of preoperative hip heterotopic ossification extent on recurrence in patients with head and spinal cord injury: a case control study. PLoS One 2011; 6(8): e23129. Dostupné z DOI: <http://dx.doi.org/10.1371/journal.pone.0023129>.

  58. Denormandie P, de l’Escalopier N, Gatin L et al. Resection of neurogenic heterotopic ossification (NHO) of the hip. Orthop Traumatol Surg Res 2018; 104(1S): S121-S127. Dostupné z DOI: <http://dx.doi.org/10.1016/j.otsr.2017.04.015>.

  59. Almangour W, Schnitzler A, Salga M et al. Recurrence of heterotopic ossification after removal in patients with traumatic brain injury: a systematic review. Ann Phys Rehabil Med 2016; 59(4): 263–269. Dostupné z DOI: <http://dx.doi.org/10.1016/j.rehab.2016.03.009>.

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