Osteolytic deposits of the pelvis leading to the diagnosis of primary hyperparathyreosis: case report


Authors: Jr Raška Ivan 1;  Rašková Mária 1;  Včelák Josef 2;  Junková Kristýna 2,3
Authors‘ workplace: III. interní klinika - endokrinologie a metabolismu 1. LF UK a VFN v Praze 1;  Endokrinologický ústav v Praze 2;  Ústav biologie a lékařské genetiky 1. LF UK a VFN v Praze 3
Published in: Clinical Osteology 2020; 25(2): 99-102
Category:

Overview

Primary hyperparatyroidism (PHPT) is a common endocrine disease and represents the most common cause of hypercalcemia. Thanks to modern diagnostic and laboratory approaches that allow us to diagnose and treat asympto­matic and mild forms of PHPT, the number of patients with clinically symptomatic PHPT decreases. The case report deals with the case of a 30 year old woman who underwent medical examination due to renal colic. Nephrolithiasis and multiple osteolytic lesions in the pelvic area were found on CT. A differential diagnostic examination was initiated considering a hematological malignancy that was excluded. After calcium-phosphate metabolism examination clinically symptomatic PHPT diagnosis was set.

Keywords:

primary hyperparathyroidism – brown tumor – osteolytic leasons


Sources

Yu N, Donnan PT, Murphy JM et al. Epidemiology of Primary Hyperparathyroidism in Tayside, Scotland, UK. Clin Endocrinol (Oxf) 2009; 71(4): 485–493. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365–2265.2008.03520.x>.

Adami S, Marcocci C, Gatti D. Epidemiology of Primary Hyperparathyroidism in Europe. J Bone Miner Res 2002; 17(Suppl 2): N18-N23.

Bilezikian JP, Bandeira L, Khan A et al. Hyperparathyroidism. Lancet 2018; 391(10116): 168–178. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(17)31430–7>.

Shane E. Clinical review 122: Parathyroid Carcinoma. J Clin Endocrinol Metab 2001; 86(2): 485–493. Dostupné z DOI: <http://dx.doi.org/10.1210/jcem.86.2.7207>.

Rosa J, Raska I Jr, Wichterle D et al. Pulse Wave Velocity in Primary Hyperparathyroidism and Effect of Surgical Therapy Hypertens Res 2011; 34(3): 296–300. Dostupné z DOI: <http://dx.doi.org/10.1038/hr.2010.232>.

Pepe J, Cipriani C, Sonato C et al. Cardiovascular manifestations of primary hyperparathyroidism: a narrative review. Eur J Endocrinol 2017; 177(6): R297-R308. Dostupné z DOI: <http://dx.doi.org/10.1530/EJE-17–0485>.

Silverberg SJ, Bilezikian JP. Evaluation and management of primary hyperparathyroidism. J Clin Endocrinol Metab 1996: 81(6): 2036–2040. Dostupné z DOI: <http://dx.doi.org/10.1210/jcem.81.6.8964825>.

Bilezikian JP, Brandi ML, Rubin SJ et al. Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med 2005; 257(1): 6–17. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365–2796.2004.01422.x>.

Can O, Boynueğri B, Gökçe Özgür Can O et al. Brown Tumors: A Case Report and Review of the Literature 2016. Case Rep Nephrol Dial 2016; 6(1): 46–52. Dostupné z DOI: <http://dx.doi.org/10.1159/000444703>.

Bandeira F, Cusano NE, Silva BC et al. Bone disease in primary hyperparathyroidism. Arq Bras Endocrinol Metabol 2014; 58(5): 553–561. Dostupné z DOI: <http://dx.doi.org/10.1590/0004–2730000003381>.

Ullah E, Ahmad M, Ali SA et al. Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy. Indian J Endocrinol Metab 2012; 16(6): 1040–1042. Dostupné z DOI: <http://dx.doi.org/10.4103/2230–8210.103037>.

Misiorowski W, Czajka-Oraniec I, Kochman M et al. Osteitis Fibrosa Cystica-A Forgotten Radiological Feature of Primary Hyperparathyroidism Endocrine 2017; 58(2): 380–385. Dostupné z DOI: <http://dx.doi.org/10.1007/s12020–017–1414–2>.

Panagopoulos A, Tatani I, Kourea HP et al. Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report. J Med Case Rep 2018; 12(1): 176. Dostupné z DOI: <http://dx.doi.org/10.1186/s13256–018–1723-y>.

Labels
Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology
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