Early non-responders in teriparatide therapy: retrospective analysis


Authors: Masaryk Pavol;  Letkovská Alexandra
Authors‘ workplace: Národný ústav reumatických chorôb, Piešťany
Published in: Clinical Osteology 2020; 25(1): 45-49
Category:

Overview

Teriparatide (TPTD) is a potent osteoanabolic drug. A potential drawback associated with teriparatide treatment is a failure of effect. The incidence of non-responders depends on the definition of lack of response to treatment, baseline bone density, duration of treatment, prior antiresorptive therapy, and measurement accuracy. In our study, we analyzed “early non-responders” after 6 and 12 months of treatment in a group of 306 patients. We identified 36 (11.7 %) patients as early non-responders, of whom 18 after 6 months of treatment and 18 after one year of treatment. There were only 4 men and up to 32 women in the sample, but the percentage of non-responders among the sexes was approximately the same (men: 10.5 %, women: 11.9 %). Early non-responders in glucocorticoid osteoporosis were significantly more represented. Previous antiresorptive therapy, especially bisphosphonates, increased the risk of a lack of response to teriparatide therapy.

Keywords:

teriparatide – non-responders


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Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology
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