Effect of long-term treatment with growth hormone on bone density and bone quality

Authors: Kužma Martin;  Stojkovičová Dáša;  Payer Juraj
Authors‘ workplace: V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
Published in: Clinical Osteology 2019; 24(1): 23-26


Growth hormone (GH) affects bone metabolism directly by binding to GH receptor or indirectly by IGF-1. The anabolic effect of GH is essential for peak bone mass (PBM) and appropriate trabecular bone microarchitecture during adolescence and early adulthood. In short-term studies, the effect of GH replacement on bone mineral density (BMD) in adults with GH deficiency (GHD) was not observed. BMD increases are only observed in studies longer than 12–24 months. A gradual rise in BMD was then observed even after 5–7 years of GH treatment. At present, it is believed that impaired bone strength and microstructure is more important in fracture development than BMD. Although short-term studies have confirmed the positive effect of RH treatment on bone quality parameters, long-term data are insufficient.


bone mineral density – growth hormone – peak bone mass

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Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology
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